Other Brands/Names

In Indonesia, alfuzosin hydrochloride is sold under the brand name Xatral XL.

How it Works

Alfuzosin hydrochloride is a medicine commonly used to treat benign prostatic hyperplasia (BPH), a condition where the prostate gland enlarges in older men. Although BPH is not cancerous or malignant, the size of enlarged gland can still press on the bladder and cause frequent difficulty in urination.

This medication works by relaxing the muscles in the prostate and bladder neck, which helps improve urine flow.

Indications

Alfuzosin hydrochloride is used for treating benign prostatic hyperplasia. Additionally, this medicine can also be prescribed as a supportive treatment with catheterization in older men with urination problems due to BPH

Contraindications

This medicine should not be taken by people with the following conditions:

• Allergy or hypersensitivity to alfuzosin hydrochloride, often marked by rashes or hives

• A history of orthostatic hypotension (a sudden drop in blood pressure upon standing)

• Severe liver disorders

• Severe kidney disorders

• Taken together with antifungal drugs such as ketoconazole or itraconazole

Side Effects

Side effects are uncommon, but may include:

• Palpitations

• Upper respiratory tract infection

• Chest pain

• Diarrhea

• Headache

• Dizziness

• Itching

• Hives

• Abdominal pain

Types

Currently, alfuzosin hydrochloride is available as a 10 mg slow-release tablet.

Dosage

• Adult dosage: 2.5 mg taken three times daily, not exceeding 10 mg per day. The first dose is usually recommended before bedtime.
• Elderly dosage: 2.5 mg twice daily for 3–4 days.

Safety

Pregnancy:

This medicine is classified under FDA Category B. Animal studies have not shown harmful effects on the fetus, but adequate human studies are lacking. Its use in pregnant women should be considered carefully, but it is generally regarded as safe.

Drug Interactions

Antifungal medicines (ketoconazole or itraconazole)

Taking alfuzosin hydrochloride at the same time as antifungal drugs can increase the drug’s concentration in the blood, raising the risk of side effects. The concurrent use of alfuzosin hydrochloride and ketoconazole should be under strict medical supervision.

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