Tanya Dokter

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Pertanyaan Anda
Jumat, 13 Oktober 2023 | 16:08
Darah

Sel darah putih

AM
Info Penanya : AM

Apa yang terjadi kalau orang kekurangan darah putih? apakah itu ciri-ciri kanker?

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Dijawab Oleh
Dijawab Oleh : dr. Giovanni Frans Alvin

Hai, terima kasih telah bertanya di Tanya Dokter Ai Care

Sel darah putih atau leukosit merupakan salah satu komponen darah. Namun, jumlahnya hanya <1% dari total darah. Keadaan di mana produksi sel darah putih kurang dari jumlah normal disebut leukopenia. 

Sel darah putih diproduksi oleh bagian tubuh Anda yang dikenal dengan sumsum tulang belakang. Walaupun jumlahnya hanya sedikit, sel darah putih memiliki fungsi yang penting bagi Anda. Sel darah putih menjaga tubuh Anda tetap sehat dengan menyerang virus, bakteri, parasit dan jamur. Ketika jumlah sel darah putih terlalu rendah, tubuh akan mudah terinfeksi dan terserang penyakit.

Penyakit tertentu yang sering menyebabkan penurunan jumlah sel darah putih antara lain infeksi menahun, kelainan bawaan dari orangtua, dan gangguan autoimun. Penyebab lainnya antara lain efek samping obat, malnutrisi dan kanker.

Infeksi yang berlangsung bertahun-tahun seperti tuberculosis dan HIV/AIDS adalah salah satu penyebab leukopenia. Pada kondisi ini, tubuh dipaksa untuk melawan bakteri dan virus terus menerus dalam jangka waktu lama. Begitu juga dengan kelainan darah seperti anemia aplastik dan gangguan autoimun seperti lupus.

Kekurangan vitamin B12, zinc, dan asam folat bisa menghambat produksi sel darah putih.  Leukopenia juga dapat timbul akibat efek samping mengkonsumsi obat-obatan tertentu dalam jangka panjang. Obat tersebut antara lain antibiotik, tiroid, antipsikotik, kortikosteroid dan kemoterapi. 

Jika bagian yang memproduksi sel darah putih terganggu, maka jumlahnya akan menurun. Kondisi tersebut dapat terjadi akibat kanker sumsum tulang dan kanker darah seperti leukemia.

Mengenai pertanyaan Anda, gejala yang muncul jika seseorang kekurangan sel darah putih bermacam-macam dan tidak selalu dikaitkan dengan kanker. Gejala tersebut antara lain, sering mengalami demam dengan suhu lebih dari 38 derajat celcius, sering mengalami penyakit infeksi, mudah muncul ruam tiba-tiba pada kulit dan sariawan, mudah lelah, kehilangan nafsu makan dan penurunan berat badan progresif.

Saat ini Anda dapat menjaga kesehatan secara umum seperti rutin berolahraga, diet sehat, mengurangi merokok dan konsumi alkohol, serta mencoba mencari tahu apakah ada anggota keluarga yang memiliki riwayat kekurangan sel darah putih.

Bila Anda memiliki atau menemukan teman, saudara, kerabat yang memiliki gejala seperti sering demam, diare dan batuk yang tidak kunjung sembuh, dan sesak nafas, dianjurkan untuk berkonsultasi dengan dokter terutama dokter penyakit dalam. Pengobatan penyakit akan disesuaikan dengan tingkat keparahannya.

Semoga jawaban ini membantu Anda. Bila mengalami keluhan kesehatan atau ingin bertanya seputar informasi kesehatan, dapat berkonsultasi langsung dengan dokter di Aplikasi Ai Care. Unduh Aplikasi Ai Care di Appstore dan Playstore Anda!

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darah putih darah
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Baca Juga
Pilihan Makanan yang Dapat Meningkatkan Hemoglobin (Hb) Mengenal Struktur dan Fungsi Plasma Darah Beragam Kondisi Kelainan Darah dan Faktor Penyebabnya Serba-Serbi Donor Plasma
Silahkan Klik "Tanya Dokter" Untuk Mengajukan Pertanyaan Anda
Tanya Dokter

Diskusi Terbaru

Selasa, 6 Mei 2025 | 02:39

muncul uban di usia 20 tahun

HD
Info Penanya : HD
Dijawab Oleh :

apakan normal muncul uban di usia 20 tahun?

Belum Dijawab
Senin, 5 Mei 2025 | 22:18
Alergi dan Sistem Imun

alergi

RU
Info Penanya : RU
Dijawab Oleh : dr. Reynaldi Syarifu Rachman

saya punya alergi dari kecil, sy sdh cek darah igE total nya 103.9 UI/ml normal atau tidak?

Dibalas
Senin, 5 Mei 2025 | 16:06
Sistem Reproduksi & Genitalia

obat alami

MU
Info Penanya : MU
Dijawab Oleh : dr. Ayu Munawaroh, MKK

Dok sodara saya kemaluan pria ny Tersiram obat rumput sehingga menyebab kan koreng pada kemaluan ny ,dan saya boleh mnta resep obat alami ny

Dibalas

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Testing Post 12 Desember 2024 v1
MessagesTimelineExceptionsViews4RouteQueries39Models392Livewire0MailsGateSessionRequest
Request history8.1.29PHP Version703msRequest Duration4MBMemory UsageGET discussions/{slug}Route
    • Booting (257ms)time
    • Application (446ms)time
    • 1 x Application (63.43%)
      446ms
      1 x Booting (36.57%)
      257ms
      4 templates were rendered
      • 1x web.v2.discussion.showshow.blade.php#?blade
      • 1x web.v2.partials.article-populararticle-popular.blade.php#?blade
      • 1x web.v2.partials.related-articlerelated-article.blade.php#?blade
      • 1x layouts.v2.web_layoutweb_layout.blade.php#?blade
      uri
      GET discussions/{slug}
      middleware
      web
      controller
      App\Http\Controllers\DiscussionController@show
      namespace
      App\Http\Controllers
      prefix
      where
      as
      web.discussion.show
      file
      app/Http/Controllers/DiscussionController.php:158-228
      39 statements were executed (4 duplicates)Show only duplicates343ms
      • DiscussionController.php#164aicare_prod_new1.51msselect * from `questions` where `slug` = 'sel-darah-putih' and `questions`.`deleted_at` is null limit 1
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        • Use SELECT * only if you need all columns from table
        • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
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        • app/Http/Controllers/DiscussionController.php:164
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • DiscussionController.php#178aicare_prod_new1.12msselect * from `questions` where `slug` = 'sel-darah-putih' and `questions`.`deleted_at` is null limit 1
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        • app/Http/Controllers/DiscussionController.php:178
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • DiscussionController.php#191aicare_prod_new5.33msselect column_name as `name`, data_type as `type_name`, column_type as `type`, collation_name as `collation`, is_nullable as `nullable`, column_default as `default`, column_comment as `comment`, extra as `extra` from information_schema.columns where table_schema = 'aicare_prod_new' and table_name = 'questions' order by ordinal_position asc
        Backtrace
        • app/Http/Controllers/DiscussionController.php:191
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • DiscussionController.php#191aicare_prod_new10.87msupdate `questions` set `views` = 260, `questions`.`updated_at` = '2025-05-07 23:55:28' where `id` = 108
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        • app/Http/Controllers/DiscussionController.php:191
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • DiscussionController.php#199aicare_prod_new1.49msselect * from `answers` where `answers`.`question_id` = 108 and `answers`.`question_id` is not null and `answers`.`deleted_at` is null
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        Backtrace
        • app/Http/Controllers/DiscussionController.php:199
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • DiscussionController.php#200aicare_prod_new1.37msselect `tags`.*, `answer_tag`.`answer_id` as `pivot_answer_id`, `answer_tag`.`tag_id` as `pivot_tag_id`, `answer_tag`.`created_at` as `pivot_created_at`, `answer_tag`.`updated_at` as `pivot_updated_at` from `tags` inner join `answer_tag` on `tags`.`id` = `answer_tag`.`tag_id` where `answer_tag`.`answer_id` = 108
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        • app/Http/Controllers/DiscussionController.php:200
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • DiscussionController.php#208aicare_prod_new1.83msselect * from `categories` where `type` = 'healthpedia' and `parent_id` <> 0 and `categories`.`deleted_at` is null
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        • app/Http/Controllers/DiscussionController.php:208
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • DiscussionController.php#209aicare_prod_new163msselect * from `posts` where `status` = 1 and `publish_date` <= '2025-05-07 23:55:28' and `content_type` = 'article' and `posts`.`deleted_at` is null order by RAND() limit 7
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        • 2: article
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        • ORDER BY RAND() is slow, try to avoid if you can. You can read this or this
        Backtrace
        • app/Http/Controllers/DiscussionController.php:209
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • DiscussionController.php#210aicare_prod_new1.38msselect * from `posts` where `status` = 1 and `publish_date` <= '2025-05-07 23:55:28' and `content_type` = 'article' and `posts`.`deleted_at` is null order by `id` desc limit 4
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        • 1: 2025-05-07 23:55:28
        • 2: article
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        Backtrace
        • app/Http/Controllers/DiscussionController.php:210
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • DiscussionController.php#213aicare_prod_new18.63msselect * from `posts` where `status` = 1 and `publish_date` <= '2025-05-07 23:55:28' and `content_type` = 'article' and exists (select * from `tags` inner join `post_tag` on `tags`.`id` = `post_tag`.`tag_id` where `posts`.`id` = `post_tag`.`post_id` and `tags`.`id` in (7806, 3916)) and `posts`.`deleted_at` is null order by RAND() limit 5
        Bindings
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        • 1: 2025-05-07 23:55:28
        • 2: article
        • 3: 7806
        • 4: 3916
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        • ORDER BY RAND() is slow, try to avoid if you can. You can read this or this
        Backtrace
        • app/Http/Controllers/DiscussionController.php:213
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • DiscussionController.php#224aicare_prod_new5.13msselect * from `questions` where `status` = 'published' and `questions`.`deleted_at` is null order by `id` desc
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        • app/Http/Controllers/DiscussionController.php:224
        • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
        • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
      • show.blade.php#109aicare_prod_new960μsselect * from `categories` where `categories`.`id` = 21 and `categories`.`deleted_at` is null limit 1
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        • view::web.v2.discussion.show:109
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
      • show.blade.php#176aicare_prod_new1.14msselect * from `answers` where `answers`.`question_id` = 108 and `answers`.`question_id` is not null and `answers`.`deleted_at` is null order by `id` desc limit 1
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        • view::web.v2.discussion.show:176
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
      • show.blade.php#205aicare_prod_new1.05msselect `tags`.*, `answer_tag`.`answer_id` as `pivot_answer_id`, `answer_tag`.`tag_id` as `pivot_tag_id`, `answer_tag`.`created_at` as `pivot_created_at`, `answer_tag`.`updated_at` as `pivot_updated_at` from `tags` inner join `answer_tag` on `tags`.`id` = `answer_tag`.`tag_id` where `answer_tag`.`answer_id` = 108
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        • view::web.v2.discussion.show:205
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
      • show.blade.php#257aicare_prod_new6.78msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 8246 and `categories`.`deleted_at` is null
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        • view::web.v2.discussion.show:257
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
      • show.blade.php#257aicare_prod_new6.7msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 7183 and `categories`.`deleted_at` is null
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        • view::web.v2.discussion.show:257
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
      • show.blade.php#257aicare_prod_new6.54msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 1410 and `categories`.`deleted_at` is null
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        Backtrace
        • view::web.v2.discussion.show:257
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
      • show.blade.php#257aicare_prod_new6.43msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 7175 and `categories`.`deleted_at` is null
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        • Use SELECT * only if you need all columns from table
        Backtrace
        • view::web.v2.discussion.show:257
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
      • show.blade.php#366aicare_prod_new1.08msselect * from `answers` where `answers`.`question_id` = 341 and `answers`.`question_id` is not null and `answers`.`deleted_at` is null order by `id` desc limit 1
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        • 0: 341
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        Backtrace
        • view::web.v2.discussion.show:366
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
      • show.blade.php#336aicare_prod_new990μsselect * from `categories` where `categories`.`id` = 9 and `categories`.`deleted_at` is null limit 1
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        • 0: 9
        Hints
        • Use SELECT * only if you need all columns from table
        • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
        Backtrace
        • view::web.v2.discussion.show:336
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
      • show.blade.php#366aicare_prod_new1.14msselect * from `answers` where `answers`.`question_id` = 340 and `answers`.`question_id` is not null and `answers`.`deleted_at` is null order by `id` desc limit 1
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        • 0: 340
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        • Use SELECT * only if you need all columns from table
        Backtrace
        • view::web.v2.discussion.show:366
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
      • show.blade.php#336aicare_prod_new1.17msselect * from `categories` where `categories`.`id` = 25 and `categories`.`deleted_at` is null limit 1
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        • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
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        • view::web.v2.discussion.show:336
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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        • 0: 4296
        Hints
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        Backtrace
        • view::web.v2.partials.article-popular:8
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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        Backtrace
        • view::web.v2.partials.article-popular:8
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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        Backtrace
        • view::web.v2.partials.article-popular:11
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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        Hints
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        Backtrace
        • view::web.v2.partials.article-popular:8
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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        Hints
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        Backtrace
        • view::web.v2.partials.article-popular:8
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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        Hints
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        Backtrace
        • view::web.v2.partials.article-popular:8
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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        • 0: 4540
        Hints
        • Use SELECT * only if you need all columns from table
        Backtrace
        • view::web.v2.partials.article-popular:8
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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        Backtrace
        • view::web.v2.partials.article-popular:8
        • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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        • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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        Backtrace
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        Backtrace
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        Backtrace
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        Backtrace
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        Backtrace
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        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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        • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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