Natriuretic Peptide

Natriuretic Peptide
credits: google.com

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Definisi

Natriuretic Peptide atau peptida natriuretic adalah protein hormon yang dihasilkan oleh jantung dan pembuluh darah.  Protein hormon tersebut memiliki 2 tipe, yaitu:

  • Brain Natriuretic Peptide (BNP)
  • Nterminal pro b-type natriuretic peptide (NT-proBNP)

BNP memiliki peran penting dalam mengatur sirkulasi darah. BNP dapat membuat pembuluh darah melebar atau mengalami dilatasi. Umumnya, kadar kedua tipe BNP tersebut jumlahnya kecil dalam darah. 

Melalui pemeriksaan ini, petugas kesehatan atau dokter dapat mendapatkan informasi mengenai kesehatan jantung maupun ginjal Anda. Bila BNP ini ditemukan dalam jumlah yang lebih tinggi dalam pembuluh darah, hal ini dapat menandakan jantung Anda kurang dapat memompa darah sesuai dengan kebutuhan tubuh. Kondisi tersebut dikenal sebagai gagal jantung.

Selain itu, hasil pemeriksaan BNP yang tinggi juga dapat menandakan ginjal Anda kurang dapat berfungsi dengan baik.

 

Indikasi

Pemeriksaan BNP umumnya diindikasikan untuk membantu diagnosis dan perawatan gagal jantung. Pemeriksaan ini juga berfungsi untuk:

  • Membantu dokter dalam mendiagnosis tingkat keparahan kondisi gangguan jantung, terutama bila menunjukkan gejala gagal jantung seperti kesulitan bernapas.
  • Membantu dokter dalam menentukan perawatan atau pengobatan yang akan diberikan pada kondisi pasien yang memerlukan perawatan lebih lanjut bila gagal jantung memburuk hingga rawat inap.
  • Membantu dokter dalam mengevaluasi pengobatan gagal jantung berjalan dengan baik dan efektif.

 

Kontraindikasi

Tidak ada kontraindikasi khusus terkait pemeriksaan BNP dalam darah.

 

Persiapan Sebelum Pemeriksaan

Pemeriksaan BNP dalam darah tidak membutuhkan persiapan khusus. Bila Anda menjalani pemeriksaan lain, maka Anda akan diminta untuk berpuasa (tidak makan) beberapa jam sebelum pemeriksaan dilakukan. Beberapa obat mungkin dapat mempengaruhi hasil pengujian, sehingga sebaiknya Anda memberikan informasi pada dokter Anda.

 

Prosedur pemeriksaan

Pemeriksaan BNP dilakukan dengan mengambil sedikit darah dari pembuluh darah balik di lengan. Pada bayi, darah diambil di bagian tumit. Selanjutnya, darah akan dimasukan ke dalam tabung darah dan diperiksa oleh mesin khusus. Prosedur ini hanya berlangsung sekitar 15 menit dan Anda dapat beraktivitas kembali.

Beberapa orang merasakan nyeri, pusing, dan memar saat pengambilan darah. Namun, hal ini biasanya hilang dengan cepat.

 

Nilai Normal dan Abnormal

Hasil ini pemeriksaan BNP dibagi menjadi:

  • Normal: Kurang dari 100 pg/mL
  • Tinggi: Lebih dari 400 pg/mL
  • Memerlukan pertimbangan dokter : 100 – 400 pg/mL

Hasil pemeriksaan juga dapat dibagi berdasarkan usia, yaitu:

Kondisi

Usia

Nilai BNP (pg/mL)

Normal

Segala usia

Kurang dari 300

Kemungkinan adanya gagal jantung

Di bawah 50 tahun

Lebih dari 450

Kemungkinan adanya gagal jantung

50 – 75 tahun

Lebih dari 900

Kemungkinan adanya gagal jantung

Lebih dari 75 tahun

Lebih dari 1000

 

Selain itu, hasil nilai pemeriksaan NT-proBNP dibagi menjadi:

  • Normal: <300 ng/L
  • Memerlukan pertimbangan dokter: 
    • Usia <50 tahun: <450 ng/L
    • Usia 50-75 tahun: <900 ng/L
    • Usia >75 tahun: <1800 ng/L
  •  Tinggi:
    • Usia <50 tahun: >450 ng/L
    • Usia 50-75 tahun: >900 ng/L
    • Usia >75 tahun: >1800 ng/L

 

Hasil dan Saran (Pemeriksaan Lanjutan)

Normal

Pemeriksaan kadar BNP darah dengan hasil dalam rentang normal menunjukan keseimbangan dan kondisi tubuh Anda baik, terutama kondisi jantung dan ginjal. Pertahankan kesehatan Anda dengan mengonsumsi diet gizi seimbang, aktivitas fisik, serta pemeriksaan kesehatan rutin.

 

Tinggi

Hasil pemeriksaan BNP dalam darah yang tinggi menandakan beberapa kondisi, seperti:

  • Adanya kemungkinan gagal jantung.
  • Gagal ginjal atau sedang dalam proses cuci darah (dialisis)
  • Beberapa gangguan pernapasan (pneumonia, gangguan paru, PPOK)
  • Gangguan jantung lainnya seperti atrial fibrilasi, penyakit otot jantung, dan lain-lain

Nilai BNP yang lebih tinggi dapat juga dipengaruhi oleh usia, jenis kelamin, berat badan (Body Mass Index), riwayat kesehatan, dan faktor lainnya. Nilai BNP pada wanita umumnya cenderung lebih tinggi dibandingkan pria. Selain itu, orang yang obesitas cenderung memiliki nilai BNP lebih rendah. Untuk hasil yang lebih spesifik, Anda dapat mendiskukannya dengan dokter.

 

Konsultasikan ke Dokter yang Tepat

Bila hasil perhitungan BNP dalam darah Anda tidak normal, Anda dapat berkonsultasi dengan dokter umum untuk mendapatkan diagnosis dan terapi yang sesuai. Bila diperlukan, Anda juga dapat berkonsultasi dengan dokter spesialis penyakit dalam. Anda juga dapat berkonsultasi dengan dokter spesialis anak mengenai hasil BNP anak.

 

Mau tahu informasi seputar hasil pemeriksaan laboratorium, radiologi, dan lainnya? Cek di sini, ya!

Writer : dr Kevin Luke
Editor :
  • dr Ayu Munawaroh, MKK
Last Updated : Jumat, 14 April 2023 | 09:51

BNP and NT-proBNP. (2022). Retrived 05 August  2022, from https://www.testing.com/tests/bnp-and-nt-probnp/

Natriuretic Peptide Test (BNP, NT-proBNP). (2022). Retrieved 05 August 2022, from https://medlineplus.gov/lab-tests/natriuretic-peptide-tests-bnp-nt-probnp/

B-Type Natriuretic Peptide (BNP) Test. (2022). Retrieved 05 August 2022, from https://my.clevelandclinic.org/health/diagnostics/22629-b-type-natriuretic-peptide

Heart Failure and the BNP Blood Test. (2020). Retrieved 05 August 2022, from https://www.webmd.com/heart-disease/heart-failure/bnp-blood-test

BNP (Blood). (2022). Retrieved 05 August 2022, from

https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=bnp_blood

BNP : An Importat Cardiac Test. (2022). Retrieved 05 August 2022, from https://www.health.harvard.edu/newsletter_article/bnp-an-important-new-cardiac-test

BNP Testing. (2022), Retrieved 05 August 2022, from https://stanfordhealthcare.org/medical-tests/b/blood-test/types/bnp-testing.html

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      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • WebController.php#1386aicare_prod_new23.99msselect `posts`.*, `post_tag`.`tag_id` as `pivot_tag_id`, `post_tag`.`post_id` as `pivot_post_id` from `posts` inner join `post_tag` on `posts`.`id` = `post_tag`.`post_id` where `post_tag`.`tag_id` = 6878 and `posts`.`deleted_at` is null
      Bindings
      • 0: 6878
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • app/Http/Controllers/WebController.php:1386
      • app/Http/Controllers/WebController.php:372
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • WebController.php#1386aicare_prod_new23.3msselect `posts`.*, `post_tag`.`tag_id` as `pivot_tag_id`, `post_tag`.`post_id` as `pivot_post_id` from `posts` inner join `post_tag` on `posts`.`id` = `post_tag`.`post_id` where `post_tag`.`tag_id` = 6879 and `posts`.`deleted_at` is null
      Bindings
      • 0: 6879
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • app/Http/Controllers/WebController.php:1386
      • app/Http/Controllers/WebController.php:372
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • WebController.php#1386aicare_prod_new13.51msselect `posts`.*, `post_tag`.`tag_id` as `pivot_tag_id`, `post_tag`.`post_id` as `pivot_post_id` from `posts` inner join `post_tag` on `posts`.`id` = `post_tag`.`post_id` where `post_tag`.`tag_id` = 6880 and `posts`.`deleted_at` is null
      Bindings
      • 0: 6880
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • app/Http/Controllers/WebController.php:1386
      • app/Http/Controllers/WebController.php:372
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • CategoryHealtTopics.php#11aicare_prod_new920μsselect * from `categories` where (`slug` != 'penyakit-a-z' and `slug` != 'obat-a-z' and `slug` != 'pemeriksaan-a-z' and `parent_id` = '0') and `categories`.`deleted_at` is null order by `order` asc
      Bindings
      • 0: penyakit-a-z
      • 1: obat-a-z
      • 2: pemeriksaan-a-z
      • 3: 0
      Hints
      • Use SELECT * only if you need all columns from table
      • The != operator is not standard. Use the <> operator to test for inequality instead.
      Backtrace
      • app/Repositories/Categories/CategoryHealtTopics.php:11
      • app/Http/Controllers/WebController.php:376
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • WebController.php#377aicare_prod_new160msselect * from `posts` where `status` = 1 and `publish_date` <= '2025-04-11 13:57:38' and `content_type` = 'article' and `posts`.`deleted_at` is null order by RAND() limit 7
      Bindings
      • 0: 1
      • 1: 2025-04-11 13:57:38
      • 2: article
      Hints
      • Use SELECT * only if you need all columns from table
      • ORDER BY RAND() is slow, try to avoid if you can. You can read this or this
      Backtrace
      • app/Http/Controllers/WebController.php:377
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#391aicare_prod_new8.25msupdate `posts` set `views_count` = 1414 where `id` = 4543
      Bindings
      • 0: 1414
      • 1: 4543
      Backtrace
      • app/Http/Controllers/WebController.php:391
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • ActivityLogger.php#174aicare_prod_new6.08msinsert into `activity_log` (`log_name`, `properties`, `batch_uuid`, `event`, `subject_id`, `subject_type`, `description`, `updated_at`, `created_at`) values ('default', '[]', null, 'updated', 4543, 'App\\Models\\Admin\\Post', 'updated', '2025-04-11 13:57:38', '2025-04-11 13:57:38')
      Bindings
      • 0: default
      • 1: []
      • 2: 
      • 3: updated
      • 4: 4543
      • 5: App\Models\Admin\Post
      • 6: updated
      • 7: 2025-04-11 13:57:38
      • 8: 2025-04-11 13:57:38
      Backtrace
      • vendor/spatie/laravel-activitylog/src/ActivityLogger.php:174
      • vendor/spatie/laravel-activitylog/src/Traits/LogsActivity.php:88
      • app/Http/Controllers/WebController.php:391
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • single-post-healthpedia.blade.php#37aicare_prod_new780μsselect * from `users` where `users`.`id` = 43 limit 1
      Bindings
      • 0: 43
      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::web.v2.single-post-healthpedia:37
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new6.1msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 1609 and `categories`.`deleted_at` is null
      Bindings
      • 0: 1609
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.9msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 555 and `categories`.`deleted_at` is null
      Bindings
      • 0: 555
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#11aicare_prod_new710μsselect * from `categories` where `categories`.`id` = 4 and `categories`.`deleted_at` is null limit 1
      Bindings
      • 0: 4
      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::web.v2.partials.article-popular:11
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.84msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 10137 and `categories`.`deleted_at` is null
      Bindings
      • 0: 10137
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.95msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 3869 and `categories`.`deleted_at` is null
      Bindings
      • 0: 3869
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.78msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 7983 and `categories`.`deleted_at` is null
      Bindings
      • 0: 7983
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.94msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4462 and `categories`.`deleted_at` is null
      Bindings
      • 0: 4462
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.93msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 1070 and `categories`.`deleted_at` is null
      Bindings
      • 0: 1070
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new6.07msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4564 and `categories`.`deleted_at` is null
      Bindings
      • 0: 4564
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new6.32msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4530 and `categories`.`deleted_at` is null
      Bindings
      • 0: 4530
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new5.96msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 7639 and `categories`.`deleted_at` is null
      Bindings
      • 0: 7639
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new5.99msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 7480 and `categories`.`deleted_at` is null
      Bindings
      • 0: 7480
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new5.87msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 6285 and `categories`.`deleted_at` is null
      Bindings
      • 0: 6285
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • web_layout.blade.php#122aicare_prod_new670μsselect * from `pages` where `slug` = 'about-us' limit 1
      Bindings
      • 0: about-us
      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::layouts.v2.web_layout:122
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • web_layout.blade.php#547aicare_prod_new590μsselect * from `faqs` limit 1
      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::layouts.v2.web_layout:547
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • web_layout.blade.php#551aicare_prod_new740μsselect * from `term_policies`
      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
      Backtrace
      • view::layouts.v2.web_layout:551
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    App\Models\Admin\Post
    304Post.php#?
    App\Models\Admin\Category
    21Category.php#?
    App\Models\Admin\Tag
    11Tag.php#?
    App\User
    3User.php#?
    App\Models\TermPolicy
    3TermPolicy.php#?
    App\Models\Admin\Page
    1Page.php#?
    App\Models\Admin\Faq
    1Faq.php#?
        locale
        id
        _token
        pI4lykiyxzfNJe7vk3w4PAQr1NAYW1ULqKSyXHo9
        _previous
        array:1 [ "url" => "https://ai-care.atmatech.id/healthpedia-pemeriksaan/beta-natriuretic-peptide-b...
        _flash
        array:2 [ "old" => [] "new" => [] ]
        path_info
        /healthpedia-pemeriksaan/beta-natriuretic-peptide-bnp
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
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