Desflurane

Desflurane
Credit: CRNA.

Bagikan :


Brand/Nama Lain

Nama dagang dari obat ini adalah Desprane dan Suprane.

 

Cara Kerja

Desflurane adalah obat anestesi yang bekerja dengan menghambat aktitivitas sistem saraf. Pasien akan menghirup obat ini melalui mulut untuk menerima efek seperti:

  • Penurunan kesadaran
  • Menghilangkan sensasi nyeri
  • Menekan aktivitas otot (gerakan tubuh)
  • Menurunkan refleks pasien

 

Indikasi

Obat ini digunakan untuk membuat pasien berada dalam keadaan terbius total (anestesi umum) sebelum dan setelah prosedur operasi. Desflurane bisa diberikan pada orang dewasa dan anak-anak. Pasien akan mendapat bantuan selang napas (intubasi) saat mendapat obat ini.

 

Kontraindikasi

Terdapat beberapa kondisi medis yang menjadi kontraindikasi dari penggunaan obat ini, yaitu:

  • Hipertemia maligna (peningkatan suhu tubuh yang ekstrim)
  • Memiliki faktor risiko terkena penyakit serangan jantung
  • Gangguan hati sedang dan berat
  • Mengalami kuning pada mata atau kulit (jaundice)
  • Mengalami peningkatan kadar leukosit (sel darah putih) atau justru penurunan sel darah putih eosinofil setelah menggunakan desflurane sebelumnya
  • Tidak dapat digunakan untuk anestesi pasien anak yang tidak menggunakan bantuan selang napas (intubasi)

 

Efek Samping

Efek samping yang bisa timbul setelah menggunakan obat ini adalah:

  • Peningkatan air liur
  • Kemerahan pada mata dan kelopak mata
  • Gatal pada kulit
  • Gangguan tidur atau sulit tidur

Bisa juga timbul efek samping serius yang memerlukan penanganan medis, seperti:

 

Sediaan

Obat ini tersedia dalam bentuk cairan atau larutan inhalasi, yang nantinya akan dihirup oleh pasien.

 

Dosis

Dosis desflurane yang diberikan bervariasi, tergantung usia dan respon pasien terhadap obat ini. Obat bisa diberikan bersama atau tanpa gas N2O (dinitrogen oksida).

 

Keamanan

Berdasarkan FDA (Food and Drug Administration) obat ini termasuk kategori B dalam kehamilan. Berarti, obat ini tidak menunjukkan adanya risiko pada janin saat diteliti pada hewan uji coba. Namun belum ada penelitian yang memadai pada ibu hamil. Sedangkan pada ibu menyusui belum diketahui obat ini dapat masuk ke dalam ASI atau tidak. Oleh karena itu, penggunaan obat ini pada ibu menyusui harus hati-hati.

 

Interaksi Obat

  • Dapat meningkatkan efek samping obat penghambat aktivitas otot dan saraf seperti atracurium dan pancuronium.
  • Jika digunakan dengan obat yang merelaksasikan otot (suxamethonium), dapat meningkatkan risiko terjadinya peningkatan kadar kalium dalam darah.

 

Mau tahu informasi seputar obat-obatan lainnya? Cek di sini, ya!

 

 

Writer : dr Luluk Ummaimah A
Editor :
  • dr Hanifa Rahma
Last Updated : Jumat, 14 April 2023 | 09:19

Joohi, K., & Mark, L. (2022). Desflurane (p. A single page). StatPearls Publishing. From https://www.ncbi.nlm.nih.gov/books/NBK537106/

Desflurane – Mims Indonesia. (2022). Retrieved 22 July 2022, from https://www.mims.com/indonesia/drug/info/desflurane?mtype=generic

Desflurane (inhalation route) - Mayo Clinic. Mayoclinic.org. (2021). Retrieved 22 July 2022, from https://www.mayoclinic.org/drugs-supplements/desflurane-inhalation-route/description/drg-20063377

Suprane – Rxlist. (2022). Retrieved 22 July 2022, from https://www.rxlist.com/suprane-drug.htm#warnings

FDA Pregnancy Categories – drug.com. (2022). Retrieved 22 July 2022, from https://www.drugs.com/pregnancy-categories.html

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      Backtrace
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