Atracurium Besilate

Atracurium Besilate

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Brand/nama lain

Beberapa merk dagang yang mengandung atracurium besilate di Indonesia hingga saat ini adalah Farelax, Notrixum, Surelax, Tracrium, Tramus, Tricum.

 

Cara Kerja

Atracurium besilate merupakan obat yang biasa dimanfaatkan untuk membantu proses pemasangan pipa bantu napas pada pasien yang menjalankan operasi bius umum. Atracurium besilate bekerja dengan cara menghambat asetilkolin pada sel saraf dan otot sehingga terjadi relaksasi pada otot-otot terutama saluran napas dan akhirnya membantu proses pemasangan pipa bantu napas saat di ruangan intensif rumah sakit.

 

Indikasi

Kondisi medis berupa pemasangan pipa bantu napas, membantu pemasangan ventilator mekanik saat di ruangan intensif, dan sebagai pelemas otot dalam prosedur bius umum.

 

Kontraindikasi

Kontraindikasi penggunaan atracurium besilate berupa riwayat hipersensitivitas atau alergi terhadap atracurium besilate.

 

Efek Samping

Efek samping umumnya jarang terjadi. Meskipun demikian, ada beberapa efek samping yang mungkin terjadi, misalnya bercak merah di kulit, gatal-gatal, biduran, asma, penyempitan saluran napas bronkus, kebiruan pada kulit (sianosis), penurunan denyut jantung (bradikardia), syok anafilaksis (penurunan tekanan darah akibat pemberian obat).

 

Sediaan

Beberapa sediaan atracurium besilate yang dapat ditemukan hingga saat ini adalah sebagai berikut:

  • Cairan injeksi 10 mg/mL; 25 mg/2,5 ml; 50 mg/5 mL.

 

Dosis

  • Dosis dewasa: 300 – 600 mcg/kgBB melalui suntikan pada dosis pertama selanjutkan dosis menjadi 100 – 200 mcg/kgBB melalui suntikan setiap 15 – 25 menit atau 5 – 10 mcg/kgBB/menit melalui infusan pada tindakan medis yang memerlukan waktu yang lama.
  • Dosis anak usia >1 bulan: dosis sama seperti dosis dewasa.

 

Keamanan

Kehamilan:

Termasuk FDA kategori C (terdapat penelitian pada hewan uji coba yang menunjukkan adanya efek samping pada janin namun tidak ada penelitian terkontrol baik dan memadai pada manusia) sehingga potensi manfaat dan risiko obat perlu dipertimbangkan dan digunakan dengan hati-hati pada ibu hamil.

 

Interaksi Obat

Penggunaan obat yang bersamaan antara atracurium besilat dan obat-obat antibiotik golongan aminoglikosida, dan polimiksin memiliki potensi interaksi obat berupa meningkatkan efek pelemas otot sehingga meningkatkan kejadian efek samping yang tidak diinginkan. Oleh karena itu, penggunaan obat yang bersamaan dengan atracurium besilate perlu diawasi oleh dokter untuk mencegah kejadian yang tidak diinginkan.

 

Baca lebih banyak artikel seputar obat-obatan di sini, ya!

 

Writer : dr Apri Haryono Hafid
Editor :
  • dr Ayu Munawaroh, MKK
Last Updated : Jumat, 14 April 2023 | 15:15

Badan Pengawas Obat dan Makanan. Atrakurium besilat. Available from: https://pionas.pom.go.id/monografi/atrakurium-besilat

Mims Indonesia. Atracurium besilate. Available from: https://www.mims.com/indonesia/drug/info/atracurium%20besilate?mtype=generic

Medscape. Atracurium. Available from: https://reference.medscape.com/drug/atracurium-343103

Request history8.1.29PHP Version839msRequest Duration4MBMemory UsageGET healthpedia-{category}/{slug}Route
  • warninglog[14:58:00] LOG.warning: str_contains(): Passing null to parameter #1 ($haystack) of type string is d...
  • warninglog[14:58:00] LOG.warning: str_contains(): Passing null to parameter #1 ($haystack) of type string is d...
  • infolog[14:58:00] LOG.info: Attempting to authenticate with: { "username": "administrator", "url": ...
  • Booting (262ms)time
  • Application (577ms)time
  • 1 x Application (68.72%)
    577ms
    1 x Booting (31.28%)
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    11 templates were rendered
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    • 1x web.v2.partials.healthtopichealthtopic.blade.php#?blade
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      • app/Http/Controllers/WebController.php:328
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      • app/Http/Controllers/WebController.php:328
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      • app/Http/Controllers/WebController.php:328
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      • app/Http/Controllers/WebController.php:328
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      • app/Http/Controllers/WebController.php:369
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      • app/Http/Controllers/WebController.php:1386
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      • vendor/spatie/laravel-activitylog/src/ActivityLogger.php:174
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    • article-popular.blade.php#8aicare_prod_new9.66msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 3827 and `categories`.`deleted_at` is null
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      • view::web.v2.partials.article-popular:8
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      Backtrace
      • view::web.v2.partials.article-popular:8
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      • view::web.v2.partials.article-popular:8
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      Hints
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      Backtrace
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      Hints
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      Backtrace
      • view::layouts.v2.web_layout:547
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
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      Backtrace
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      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
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