Other Brands/Names

Some of the brand names of cyproterone available on the market include:

• Androcur

• Cyproplex

• Cypron

How it Works

Cyproterone works by blocking the action of testosterone from attaching to prostate cancer cells. In addition, it lowers testosterone levels in men by sending a signal to the hypothalamus, a hormone-regulating gland in the brain, to stop releasing luteinizing hormone (LH), that normally stimulates testosterone production. Since testosterone supports the growth of prostate cancer cells, this drug can help to slow down or stop their development.

Indications

Cyproterone is prescribed for the treatment of prostate cancer. Additionally, it can also reduce excessive sexual drive and managing abnormal sexual behavior.

Contraindications

This medication should not be used by patients with the following conditions:

• Meningioma (tumor in the lining of the brain)

• Liver tumors

• Current or past stroke, or other blood vessel blockages

• Heart disease

• Severe diabetes with vascular complications

• Liver diseases

• Depression

• Children under 18 years of age who are still developing testicular function

Side Effects

Possible side effects of cyproterone include:

• Nausea and vomiting

• Dry skin and temporary hair loss

• Increased cholesterol and calcium levels in the blood

• Weight gain or weight loss

• Reduced sperm count and semen volume

• Depression

• Lowered sexual desire and erectile dysfunction

• Osteoporosis

• Higher risk of blood clots

• Long-term use at high doses may increase the risk of meningioma (tumor of the brain lining) and anemia.

Serious side effects include liver disorders such as liver inflammation, jaundice, and liver failure. Rarely, liver tumors and bleeding of stomach lining may occur.

Types

Cyproterone is available in tablet form and should be taken immediately after meals.

Dosage

The dosage of cyproterone depends on the condition being treated:

For excessive sexual drive

• The dose is 50 mg twice daily. The dose may be reduced once treatment goals are achieved, depending on patient response.

To prevent the recurrence of prostate tumors

• The dose is 200 mg daily, divided into 2–3 doses for one week. This is then followed by combination therapy with a drug that stimulates LH production for 3–4 weeks.

For long-term prostate cancer treatment

• The dose is 200 mg daily, divided into 2–3 doses.

Safety

The safety of cyproterone in pregnant and breastfeeding women has not been established. Currently, it is prescribed primarily for men, especially those with prostate cancer.

Drug Interactions

Cyproterone may interact with several other medications, such as:

• Anti-tuberculosis drugs (rifampin) and anti-seizure drugs (phenytoin), which may reduce cyproterone levels in the blood

• Cholesterol-lowering drugs (simvastatin), which can increase the risk of rhabdomyolysis (muscle breakdown)

• Antifungal drugs (ketoconazole) and antiviral drugs (ritonavir), which can interfere with cyproterone metabolism

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