Other Brands/Names

This medication is marketed under the brand names Codipront and Codipront Cum Expectorant.

How It Works

Codipront is a combination medicine made up of codeine, phenyltoloxamine, and guaifenesin. Codeine functions by acting on the brainstem’s medulla to suppress the cough reflex. It also works as a cough suppressant due to the action of phenyltoloxamine, which targets the respiratory tract. Additionally, phenyltoloxamine has anti-allergic effects that help relieve symptoms triggered by allergies.

Indications

This medicine is prescribed for the relief of dry (non-productive) cough, including coughs triggered by allergic reactions.

Contraindication

This medicine should not be taken by individuals with the following conditions:

• Lung function impairment that prevents normal oxygen intake or carbon dioxide elimination

• Acute asthma episodes

• Coma

• Enlarged prostate with urinary retention

• Narrow-angle glaucoma

• Disorders affecting the digestive tract

• Women who are pregnant or breastfeeding

• Children under 2 years of age

Side Effects

Possible side effects of Codipront include:

• Nausea and vomiting

• Skin itching

• Weight gain

• Constipation (hard stools)

• Blurred or impaired vision

• Serious risks such as breathing difficulty or respiratory failure

Types

This medication is offered in the following forms:

• Capsules containing 30 mg of codeine and 10 mg of phenyltoloxamine

• 60 ml bottle of syrup

Dosage

Dosage should be adjusted based on the patient's age and specific formulation used:

Capsules

• Adults: 1 capsule twice a day

• Children 14 years and older: 1 capsule twice a day

Syrup

• Adults and children aged 14 years old and up: 3 measuring spoons twice a day

• Children aged 6–14 years old: 2 measuring spoons twice a day

• Children aged 4–6 years old: 1 measuring spoon twice a day

• Children aged 2–4 years old: ½ measuring spoon twice a day

Safety

Codipront is classified as pregnancy category C. Animal studies have shown potential harm to the fetus, but human data are not available. The medicine is not recommended for use during breastfeeding, as codeine can pass into breast milk. Since codeine is an opioid, this medicine should only be used under medical supervision and for a short duration to prevent the risk of dependency or misuse.

Drug Interactions

Codipront can cause serious interactions when used with other drugs. These include:

• Decreased alertness and breathing difficulties when combined with:
  

  • Antipsychotics (used for mental illnesses such as schizophrenia or delusional disorders)

  • Barbiturates (sedatives and sleep-inducing medications)

  • Painkillers

  • Anti-allergy medications

• Alcohol may worsen its side effects and interfere with mental focus and decision-making.

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