Other Brands/Names

Cefoperazone Sodium, Cefophar, Stabixin-1, Nupera, Bifotik, C-Razon, Cefomax, Cepraz, Logafox, Inzon, Ferzobat, Ceropid, Biorazon.

How It Works

Cefoperazone is a member of the cephalosporin class of antibiotics. It works by halting the growth of bacteria that cause infections.

Indications

Cefoperazone is prescribed for the treatment of various bacterial infections, including those in the nose, throat, lungs, urinary tract, skin, bones, and joints.

Contraindications

People who have a history of allergies to cefoperazone or other cephalosporin antibiotics should avoid using this medication.

Side Effects

Cefoperazone may cause side effects, including:

• Pain at the injection site

• Nausea and vomiting

• Skin rash

• Decreased blood cell count

• Low hemoglobin levels

• Headache

• Fever with chills

• Elevated liver enzyme levels

Types

Cefoperazone is available in 1-gram vials of injectable powder, which is administered by injection.

Dosage

• Adults:
  • 2-4 grams per day in 2 divided doses.
  • The dose may be increased to 12 grams per day in 2-4 divided doses, administered via injection or IV.
• For patients with decreased kidney function: 1-2 grams daily.
• For patients with decreased liver function: 4 grams daily.

Safety

Cefoperazone should only be administered in a clinical or hospital setting under the supervision of a healthcare professional. Patients with a history of penicillin allergy, reduced kidney or liver function, should be closely monitored during treatment.

It is advised to avoid alcohol while using cefoperazone as it can enhance side effects like flushing (redness of the skin, typically on the face), nausea, vomiting, and an increased heart rate.

Cefoperazone should only be used during pregnancy if absolutely necessary. It is excreted in breast milk in small amounts, so it should be used with caution while breastfeeding. Always consult your doctor to discuss the risks and benefits.

Drug Interactions

• Cefoperazone can increase the effects and side effects of blood thinners (anticoagulants).

• Probenecid, a drug used to treat high uric acid levels, can raise cefoperazone blood levels.

• Cefoperazone can be fatal and increase the risk of nephrotoxicity (kidney damage) when used with:

  • Aminoglycoside antibiotics

  • Furosemide (a diuretic used to remove excess fluid caused by conditions like heart failure, liver disease, and kidney disease)

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