Dithranol

Dithranol
Dithranol tidak bisa digunakan pada penyakit psoriasis yang disertai infeksi.

Bagikan :


Brand/Nama Lain

Merek dagang dari obat ini adalah Anthramed.

 

Cara Kerja

Dithranol bekerja dengan cara menurunkan kecepatan pembelahan dan pertumbuhan sel kulit yang berlebihan pada penyakit psoriasis. Kondisi medis ini merujuk pada penyakit radang kulit kronis yang ditandai dengan sisik tebal dan bercak kemerahan. Obat ini langsung menghambat penggandaan materi genetik (DNA) dari sel.

Obat ini terbuat dari senyawa alami yang ditemukan dalam bubuk goa yang berasal dari pohon araroba. Dithranol tidak mengandung kortikosteroid.

 

Indikasi

Dithranol bisa digunakan sebagai salah satu terapi bercak kulit psoriasis jangka panjang. Psoriasis sendiri disebabkan oleh perbanyakan sel lapisan luar kulit yang lebih cepat dari normal. Hal ini akan membuat sel kulit yang sudah tua dan mati untuk menumpuk di permukaan kulit dan membentuk bercak bersisik. Obat ini bisa membantu mengontrol penyakit dengan memperlambat pembentukan sel kulit baru.

 

Kontraindikasi

Orang-orang yang memiliki riwayat alergi atau hipersensitivitas terhadap dithranol dan komponennya tidak bisa memakai obat ini. Penderita psoriasis pustular juga tidak boleh diberikan obat ini. Pustular psoriasis adalah kondisi kulit langka yang ditandai dengan bintil kekuningan berisi nanah di atas bercak kulit kemerahan. Jangan juga mengoleskan obat pada bercak kulit psoriasis yang terlihat sangat meradang.

Anak-anak, wanita hamil dan menyusui perlu mendapat perhatian khusus bila mendapat obat ini.

 

Efek Samping

Efek samping yang bisa timbul dari penggunaan obat ini adalah:

  • Rasa terbakar atau hangat pada kulit.
  • Perubahan warna pada kulit, kuku atau rambut.
  • Iritasi pada kulit

Dithranol bisa menodai kain, plastik, dan bahan-bahan lain, sehingga obat ini perlu dijauhkan dari barang tersebut. Walaupun langka, penggunaan obat ini juga dapat menyebabkan terjadinya reaksi alergi yang berlebihan dengan gejala kemerahan pada seluruh tubuh, gatal, bengkak (terutama pada wajah, mulut, mata dan lidah), pusing hingga kesulitan bernapas. Anda harus segera mencari bantuan medis bila mengalami alergi berat.

 

Sediaan

Obat ini tersedia dalam bentuk krim dengan konsentrasi 0,2%.

 

Dosis

Krim bisa dioleskan pada bagian kulit yang mengalami psoriasis selama 10-30 menit sebelum dibilas. Jangan oleskan obat pada area kulit yang tidak terkena penyakit. Dosis krim bisa ditingkatkan bertahap konsentrasinya sampai 2%. Ulangi terapi setiap hari sampai kulit terasa bersih.

 

Keamanan

Pada kehamilan, dithranol termasuk ke dalam kategori keamanan C. Hal ini berarti pada penelitian dengan hewan uji coba, obat ini menimbulkan risiko pada janin dalam kandungan hewan, walaupun masih belum ada penelitian dengan hasil yang memuaskan pada wanita hamil.

Tidak terdapat data yang cukup mengenai keamanan obat ini pada ibu menyusui. Namun molekul obat ini sangat kecil untuk bisa masuk ke dalam ASI. Sebaiknya Anda konsultasikan terlebih dahulu kepada dokter sebelum menggunakan obat ini jika sedang menyusui.

 

Interaksi Obat

Efek obat yang bisa membuat kulit sensitif dengan cahaya bisa meningkat bila berinteraksi dengan dithranol. Selain itu, bila dithranol berinteraksi dengan obat yang mengandung propilen glikol, komponen dithranol bisa menjadi tidak aktif.

 

Mau tahu informasi seputar obat-obatan lainnya? Cek di sini, ya!

 

 

Writer : dr Luluk Ummaimah A
Editor :
  • dr Hanifa Rahma
Last Updated : Minggu, 16 April 2023 | 02:37

Dithranol  – Mims Malaysia. (2022). Retrieved 6 August 2022, from https://www.mims.com/malaysia/drug/info/dithranol?mtype=generic

Anthralin Cream-Uses,Side effect and More – WebMD. (2022). Retrieved 6 Ausgust 2022, from https://www.webmd.com/drugs/2/drug-3747/anthralin-topical/details

Oakley, A. (2021). Dithranol. Dermnetnz. Retrieved 6 August 2022, from https://dermnetnz.org/topics/dithranol

Stewart, M. (2019). Dithranol For Psoriasis. Patient.info. Retrieved 6 August 2022, from https://patient.info/medicine/dithranol-for-psoriasis-dithrocream

Anthralin – Doctor Lib. (2022). Retrieved 6 August 2022, from https://doctorlib.info/pregnancy/drugs-pregnancy-lactation/65.html

Jessica, CL., Hasan, A. (2022). Pregnancy Medication (p. A single page). StatPearls Publishing. From https://www.ncbi.nlm.nih.gov/books/NBK507858/

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      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
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      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new9.25msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 49 and `categories`.`deleted_at` is null
      Bindings
      • 0: 49
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#11aicare_prod_new1.07msselect * from `categories` where `categories`.`id` = 1 and `categories`.`deleted_at` is null limit 1
      Bindings
      • 0: 1
      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::web.v2.partials.article-popular:11
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
      • 0: 4269
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new6.32msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 1017 and `categories`.`deleted_at` is null
      Bindings
      • 0: 1017
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
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      Backtrace
      • view::web.v2.partials.article-popular:11
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
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      Hints
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      Backtrace
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      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
      • 0: 3750
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
      • 0: 5627
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new6.15msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 3767 and `categories`.`deleted_at` is null
      Bindings
      • 0: 3767
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
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      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
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      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
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      Backtrace
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      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
      Backtrace
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      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
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    App\Models\Admin\Category
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