Busulfan

Busulfan
Credit: American Regent.

Kategori Obat

Hormon & Metabolisme
Obat Keras

Daftar Isi

Bagikan :


Brand/Nama Lain

Busulfex.

 

Cara Kerja

Busulfan termasuk dalam kelas obat yang disebut agen alkilasi. Obat ini akan mengganggu proses penggandaan rantai DNA dan pembentukan rantai RNA. Pada sel kanker, busulfan bekerja dengan cara memperlambat atau menghentikan pertumbuhan sel-sel kanker dalam tubuh. 

 

Indikasi

Pemberian injeksi busulfan digunakan untuk mengobati jenis kanker sel darah putih chronic myelogenous leukemia (CML) yang terjadi ketika sumsum tulang memproduksi terlalu banyak sel darah putih. Sementara itu sebagai persiapan untuk transplantasi sumsum tulang, busulfan dikombinasikan dengan obat lain.

 

Kontraindikasi

Gunakan alat kontrasepsi untuk mencegah kehamilan. Jika Anda hamil saat sedang mendapat terapi busulfan, segera hubungi dokter Anda. Busulfan dapat membahayakan janin. Tidak diketahui juga apakah obat ini dikeluarkan melalui ASI. Karena terdapat kemungkinan risiko berdampak negatif bagi bayi, tidak dianjurkan untuk menyusui saat menggunakan obat ini.

 

Efek Samping

Efek samping yang dapat terjadi dari pemberian obat ini:

  • Mual
  • Muntah
  • Diare
  • Sembelit
  • Kehilangan nafsu makan
  • Sariawan
  • Sakit perut
  • Pusing
  • Pergelangan kaki/tangan bengkak
  • Kemerahan pada kulit
  • Sakit kepala
  • Sulit tidur 

Cari bantuan medis segera jika Anda mengalami efek samping yang serius, termasuk:

  • Mual/muntah terus-menerus
  • Sakit paru yang berat
  • Kulit atau mata menguning
  • Urine berwarna gelap
  • Perubahan mental/suasana hati (seperti depresi, halusinasi, gelisah, bingung)
  • Kram otot
  • Peningkatan rasa haus
  • Sering buang air kecil
  • Detak jantung cepat atau tidak teratur
  • Batuk darah
  • Buang air kecil berdarah
  • Kejang
  • Nyeri, kemerahan, atau bengkak di tempat suntikan
  • Pingsan
  • Nyeri dada
  • Sesak napas

 

Sediaan

Busulfan tersedia dalam bentuk cairan injeksi (obat suntik) dalam vial 6 mg/ml.

 

Dosis

Dewasa

  • Dosis 0,8 mg/kg berat badan diberikan setiap 6 jam diberikan melalui infus selama 2 jam, lalu melalui kateter pada pembuluh vena sentral selama 4 hari
  • Dimulai 7 hari sebelum transplantasi sumsum tulang

Dosis Anak Berdasarkan Berat Badan

  • < 9 kg: 1 mg/kg
  • 9 - <16 kg: 1,2 mg/kg
  • 16-23 kg: 1,1 mg/kg
  • >23-34 kg: 0,95 mg/kg
  • >34kg: 0,8 mg/kg
  • Semua dosis diberikan setiap 6 jam melalui infus selama 2 jam selama 4 hari

 

Keamanan

  • Obat ini bisa membuat Anda pusing
  • Busulfan dapat membuat Anda lebih rentan terkena infeksi atau memperburuk infeksi yang Anda miliki saat ini
  • Beri tahu ahli kesehatan Anda bahwa Anda menggunakan busulfan sebelum melakukan imunisasi/vaksinasi
  • Obat ini dapat memengaruhi kesuburan pada pria dan wanita, konsultasikan dengan dokter Anda untuk informasi lebih rinci

 

Interaksi Obat

  • Pemberian busulfan bersama dengan vaksin hidup dapat meningkatkan risiko terjadinya infeksi
  • Pemberian busulfan bersama antijamur itrakonazol dan antibiotik metronidazol dapat meningkatkan kadar obat busulfan dalam darah dan risiko keracunan 
  • Dapat menyebabkan varises esofagus (kondisi pembesaran pembuluh darah di kerongkongan) jika diberikan dengan obat tioguanin (obat yang juga digunakan untuk mengobati sejenis kanker sel darah putih)

 

Mau tahu informasi seputar obat-obatan lainnya? Cek di sini, ya!

 

 

Writer : dr David Wiliam
Editor :
  • dr Hanifa Rahma
Last Updated : Jumat, 14 April 2023 | 17:19
Tags : kanker leukemia antikanker

BPOM RI. Busulfan. cekbpom.pom.go.id. Retrieved 1 April 2022, from https://cekbpom.pom.go.id//home/produk/69bhknndt7v4km8sdutf8ashf5/all/row/10/page/1/order/4/DESC/search/5/Busulfan

MIMS Indonesia. Busulfan. Mims.com. Retrieved 1 April 2022, from https://www.mims.com/indonesia/drug/info/busulfan?mtype=generic

Web MD. Busulfan Solution – Uses, Side Effects, and More. Webmd.com. Retrieved 1 April 2022, from https://www.webmd.com/drugs/2/drug-16957/busulfan-intravenous/details

Medlineplus. Busulfan Injection. Medlineplus.gov. Retrieved 1 April 2022, from https://medlineplus.gov/druginfo/meds/a611033.html    

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Request history8.1.29PHP Version889msRequest Duration6MBMemory UsageGET {category}/{slug}Route
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      Backtrace
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      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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      Hints
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      Backtrace
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      Hints
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      Backtrace
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      Backtrace
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      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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      Backtrace
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      Backtrace
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      Backtrace
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