Bicalutamide

Bicalutamide
Ilustrasi kanker prostat yang menyebabkan sumbatan atau penyempitan saluran kemih pada pria.

Bagikan :


Brand

Casodex.

 

Cara Kerja

Bicalutamide merupakan obat yang biasa dimanfaatkan untuk menangani kasus kanker prostat pada tahap lanjut, lanjut lokal, dan lanjut lokal tanpa metastasis (penyebaran ke organ lain). Bicalutamide bekerja dengan cara menghambat kinerja hormon androgen melalui pengikatan pada jaringan prostat sehingga sel tumor prostat tidak berkembang dan mengalami pengecilan ukuran tumor.

 

Indikasi

Kondisi medis berupa kanker prostat pada tahap lanjut, lanjut lokal, dan lanjut lokal tanpa metastasis (penyebaran ke organ lain).

 

Kontraindikasi

Kontraindikasi penggunaan bicalutamide berupa riwayat hipersensitivitas atau alergi terhadap bicalutamide, perempuan, anak-anak, ibu hamil dan menyusui, penggunaan obat terfenadine, astemizole, atau cisapride yang bersamaan.

 

Efek Samping

Efek samping umumnya jarang terjadi. Meskipun demikian, ada beberapa efek samping yang mungkin terjadi, misalnya reaksi alergi atau hipersensitivitas (misalnya biduran atau bengkak pada kelopak mata), nyeri pada area sekitar payudara, pembesaran payudara, radang pada liver (hepatitis), peningkatan kadar enzim liver, nyeri dada, gagal jantung, sakit perut, sulit buang air besar, mual, muntah, diare, peningkatan berat badan, penurunan nafsu makan.

 

Sediaan

Beberapa sediaan bicalutamide yang dapat ditemukan hingga saat ini adalah sebagai berikut:

  • Tablet salut selaput 50 mg; 150 mg. Dapat diminum sebelum atau setelah makan.

 

Dosis

Tujuan: untuk menangani kanker prostat tahap lanjut

Dosis dewasa: 50 mg sekali sehari bersamaan dengan terapi hormon lain

Tujuan: untuk menangani kanker prostat tahap lanjut lokal

Dosis dewasa: 150 mg sekali sehari sebagai obat tunggal atau bersamaan dengan terapi bedah atau radioterapi

Tujuan: untuk menangani kanker prostat tahap lanjut lokal tanpa metastasis

Dosis dewasa: 150 mg sekali sehari.

 

Keamanan

Kehamilan:

Termasuk FDA kategori X (terdapat penelitian pada hewan atau manusia yang menunjukkan adanya kelainan janin dan/atau terdapat bukti positif terjaidnya risiko pada janin manusia berdasarkan pada dara reaksi efek samping dari pengalaman investigasional atau pemasaran, dan risiko yang ada secara jelas melebihi dari potensi manfaatnya) sehingga tidak disarankan untuk digunakan pada ibu hamil.

 

Interaksi Obat

Obat amiodarone

Penggunaan obat yang bersamaan antara bicalutamide dan amiodarone memiliki potensi interaksi obat berupa meningkatkan risiko kejadian gangguan irama jantung berupa torsades de pointes atau pemanjangan internval QT pada hasil rekam jantung. Oleh karena itu, penggunaan obat yang bersamaan dengan bicalutamide perlu diawasi oleh dokter untuk mencegah kejadian yang tidak diinginkan.

 

Mau tahu informasi seputar obat-obatan lainnya? Cek di sini, ya!

 

 

Writer : dr Apri Haryono Hafid
Editor :
  • dr Anita Larasati Priyono
Last Updated : Rabu, 12 April 2023 | 01:36

Badan Pengawas Obat dan Makanan. Bikalutamid. Available from: https://pionas.pom.go.id/monografi/bikalutamid

Mims Indonesia. Bicalutamide. Available from: https://www.mims.com/indonesia/drug/info/bicalutamide?mtype=generic

Medscape. Bicalutamide. Available from: https://reference.medscape.com/drug/casodex-bicalutamide-342210

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      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.13msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4717 and `categories`.`deleted_at` is null
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      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new4.9msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 6328 and `categories`.`deleted_at` is null
      Bindings
      • 0: 6328
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.15msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 9168 and `categories`.`deleted_at` is null
      Bindings
      • 0: 9168
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.31msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 7462 and `categories`.`deleted_at` is null
      Bindings
      • 0: 7462
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.3msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 955 and `categories`.`deleted_at` is null
      Bindings
      • 0: 955
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::web.v2.partials.article-popular:11
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
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      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new5.26msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4964 and `categories`.`deleted_at` is null
      Bindings
      • 0: 4964
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new5.09msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4693 and `categories`.`deleted_at` is null
      Bindings
      • 0: 4693
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new5.36msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 3621 and `categories`.`deleted_at` is null
      Bindings
      • 0: 3621
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
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      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::layouts.v2.web_layout:122
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::layouts.v2.web_layout:547
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
      Backtrace
      • view::layouts.v2.web_layout:551
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    App\Models\Admin\Post
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    App\Models\Admin\Category
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    App\Models\Admin\Tag
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    App\Models\TermPolicy
    3TermPolicy.php#?
    App\User
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    App\Models\Admin\Healthpedia
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    App\Models\Admin\Page
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    App\Models\Admin\Faq
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