Artesunate

Artesunate

Kategori Obat

Infeksi
Obat Keras

Daftar Isi

Bagikan :


Brand/Nama Lain

Artesun.

Cara Kerja

Artesunate digunakan untuk membunuh parasit malaria yang hidup di dalam sel darah merah. Parasit malaria masuk ke dalam tubuh dan hidup di jaringan tubuh seperti sel darah merah atau hati. Anda perlu minum obat lain (seperti primakuin) untuk membunuh parasit malaria yang hidup di hati. Kedua perawatan tersebut diperlukan untuk kesembuhan total dan untuk menghindari kambuhnya infeksi.

Indikasi

Artesunate digunakan untuk mengobati malaria. Malaria adalah suatu infeksi yang disebabkan oleh gigitan nyamuk yang didapat saat bepergian atau tinggal di suatu wilayah di mana penyakit malaria sering terjadi (daerah endemis malaria).

Kontraindikasi

Riwayat alergi terhadap artesunate sebelumnya.

Efek Samping

  • Kelelahan yang tidak biasa dapat terjadi. Jika efek ini berlangsung lama atau memburuk, segera beri tahu dokter Anda.
  • Beritahu dokter Anda segera jika Anda memiliki efek samping yang serius, termasuk: mudah memar atau berdarah, tanda-tanda gangguan pada ginjal (seperti perubahan jumlah urin), urin berwarna gelap, mata dan kulit menguning.
  • Reaksi alergi yang sangat serius terhadap obat ini jarang terjadi. Namun, segera dapatkan bantuan medis jika Anda mengalami gejala reaksi alergi yang serius, termasuk: ruam, gatal atau bengkak (terutama pada wajah, lidah, tenggorokan), pusing hebat, dan kesulitan bernapas.

Sediaan

Artesunate tersedia dalam bentuk serbuk injeksi (bentuk serbuk yang harus dilarutkan sebelum dapat disuntikkan).

Dosis

Pengobatan awal pada kasus berat: 2,4 mg / kg melalui suntikan pembuluh darah (Intravena / IV) lambat selama 1-2 menit atau suntikan otot (Intramuskular / IM) dalam. Ulangi setelah 12 jam dan 24 jam, kemudian sesudahnya berikan suntikan sekali sehari. Ubah pemberian terapi pasien ke pengobatan oral (obat minum) lengkap yang sesuai setelah setidaknya 24 jam terapi suntikan dan setelah obat oral dapat ditoleransi. Terapi bersamaan dengan obat antimalaria lain mungkin diperlukan untuk kasus yang parah. Pertimbangkan pedoman lokal untuk pemberian pengobatan yang tepat.

Keamanan

  • Selama kehamilan, obat ini harus digunakan hanya jika benar-benar dibutuhkan. Diskusikan risiko dan manfaatnya dengan dokter Anda.
  • Obat ini dikeluarkan melalui ASI dalam jumlah kecil tetapi tidak membahayakan bayi yang menyusui. Tetap konsultasikan dengan dokter Anda sebelum menyusui.

Interaksi Obat

  • Dapat mengurangi kemanjuran artesunate jika diberikan bersama dengan obat-obat berikut: ritonavir, nevirapine, atau penginduksi UDP-glucuronosyltransferase (UGT) (misalnya rifampisin, karbamazepin, fenitoin).
  • Dapat meningkatkan risiko efek samping jika diberikan bersama dengan obat inhibitor UGT (misalnya axitinib, vandetanib, imatinib, diklofenak).
Writer : dr David Wiliam
Editor :
  • dr Ayu Munawaroh, MKK
Last Updated : Minggu, 16 April 2023 | 02:31
Tags : malaria artesunate obat malaria antiparasit

BPOM RI. Artesunate. cekbpom.pom.go.id. Retrieved 11 March 2022, from https://cekbpom.pom.go.id//home/produk/69bhknndt7v4km8sdutf8ashf5/all/row/10/page/0/order/4/DESC/search/5/artesunate

MIMS Indonesia Artesunate. Mims.com. Retrieved 11 March 2022, from https://www.mims.com/indonesia/drug/info/artesunate?mtype=generic

Web MD. Artesunate 110 Mg Intravenous Solution Antimalarial Drugs – Uses, Side Effects, and More. Webmd.com. Retrieved 11 March, from https://www.webmd.com/drugs/2/drug-179427/artesunate-intravenous/details

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Request history8.1.29PHP Version794msRequest Duration4MBMemory UsageGET {category}/{slug}Route
  • warninglog[05:22:36] LOG.warning: str_contains(): Passing null to parameter #1 ($haystack) of type string is d...
  • warninglog[05:22:36] LOG.warning: str_contains(): Passing null to parameter #1 ($haystack) of type string is d...
  • infolog[05:22:37] LOG.info: Attempting to authenticate with: { "username": "administrator", "url": ...
warninginfo
  • Booting (253ms)time
  • Application (541ms)time
  • 1 x Application (68.17%)
    541ms
    1 x Booting (31.82%)
    253ms
    11 templates were rendered
    • 1x web.v2.single-post-healthpediasingle-post-healthpedia.blade.php#?blade
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    • 1x layouts.v2.web_layoutweb_layout.blade.php#?blade
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    namespace
    App\Http\Controllers
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    app/Http/Controllers/WebController.php:645-806
    34 statements were executed (2 duplicates)Show only duplicates340ms
    • WebController.php#656aicare_prod_new770μsselect * from `categories` where (`slug` = 'obat-keras' or `slug_en` = 'obat-keras') and `categories`.`deleted_at` is null limit 1
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      • app/Http/Controllers/WebController.php:656
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#657aicare_prod_new15msselect * from `posts` where (`slug` = 'artesunate' or `slug_en` = 'artesunate') and `posts`.`deleted_at` is null limit 1
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      • app/Http/Controllers/WebController.php:657
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#703aicare_prod_new13.61msselect * from `posts` where (`slug` = 'artesunate' or `slug_en` = 'artesunate') and `status` = 1 and `publish_date` <= '2025-04-23 05:22:36' and `deleted_at` is null and `posts`.`deleted_at` is null limit 1
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      • app/Http/Controllers/WebController.php:703
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      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#703aicare_prod_new1.08msselect `users`.*, `post_editor`.`post_id` as `pivot_post_id`, `post_editor`.`user_id` as `pivot_user_id`, `post_editor`.`created_at` as `pivot_created_at`, `post_editor`.`updated_at` as `pivot_updated_at` from `users` inner join `post_editor` on `users`.`id` = `post_editor`.`user_id` where `post_editor`.`post_id` in (3005)
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      • app/Http/Controllers/WebController.php:703
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      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#703aicare_prod_new920μsselect `users`.*, `post_english_editors`.`post_id` as `pivot_post_id`, `post_english_editors`.`user_id` as `pivot_user_id`, `post_english_editors`.`created_at` as `pivot_created_at`, `post_english_editors`.`updated_at` as `pivot_updated_at` from `users` inner join `post_english_editors` on `users`.`id` = `post_english_editors`.`user_id` where `post_english_editors`.`post_id` in (3005)
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      • app/Http/Controllers/WebController.php:703
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    • WebController.php#703aicare_prod_new5.9msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` in (3005) and `categories`.`deleted_at` is null
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      • app/Http/Controllers/WebController.php:703
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#703aicare_prod_new770μsselect * from `categories` where `categories`.`id` in (0) and `categories`.`deleted_at` is null
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      • app/Http/Controllers/WebController.php:703
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#721aicare_prod_new840μsselect * from `categories` where `categories`.`id` = 8 and `categories`.`deleted_at` is null limit 1
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      • app/Http/Controllers/WebController.php:721
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#724aicare_prod_new18.23msselect `tags`.*, `post_tag`.`post_id` as `pivot_post_id`, `post_tag`.`tag_id` as `pivot_tag_id`, `post_tag`.`created_at` as `pivot_created_at`, `post_tag`.`updated_at` as `pivot_updated_at` from `tags` inner join `post_tag` on `tags`.`id` = `post_tag`.`tag_id` where `post_tag`.`post_id` = 3005
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      • app/Http/Controllers/WebController.php:724
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#1360aicare_prod_new12.42msselect `posts`.*, `post_tag`.`tag_id` as `pivot_tag_id`, `post_tag`.`post_id` as `pivot_post_id` from `posts` inner join `post_tag` on `posts`.`id` = `post_tag`.`post_id` where `post_tag`.`tag_id` = 3971 and `posts`.`deleted_at` is null
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      • app/Http/Controllers/WebController.php:1360
      • app/Http/Controllers/WebController.php:735
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      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • WebController.php#1360aicare_prod_new11.63msselect `posts`.*, `post_tag`.`tag_id` as `pivot_tag_id`, `post_tag`.`post_id` as `pivot_post_id` from `posts` inner join `post_tag` on `posts`.`id` = `post_tag`.`post_id` where `post_tag`.`tag_id` = 5660 and `posts`.`deleted_at` is null
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      • app/Http/Controllers/WebController.php:1360
      • app/Http/Controllers/WebController.php:735
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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    • WebController.php#1360aicare_prod_new12.06msselect `posts`.*, `post_tag`.`tag_id` as `pivot_tag_id`, `post_tag`.`post_id` as `pivot_post_id` from `posts` inner join `post_tag` on `posts`.`id` = `post_tag`.`post_id` where `post_tag`.`tag_id` = 5661 and `posts`.`deleted_at` is null
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      • app/Http/Controllers/WebController.php:1360
      • app/Http/Controllers/WebController.php:735
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • WebController.php#1360aicare_prod_new11.78msselect `posts`.*, `post_tag`.`tag_id` as `pivot_tag_id`, `post_tag`.`post_id` as `pivot_post_id` from `posts` inner join `post_tag` on `posts`.`id` = `post_tag`.`post_id` where `post_tag`.`tag_id` = 5662 and `posts`.`deleted_at` is null
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      • app/Http/Controllers/WebController.php:1360
      • app/Http/Controllers/WebController.php:735
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • WebController.php#739aicare_prod_new109msselect * from `posts` where `status` = 1 and `publish_date` <= '2025-04-23 05:22:37' and `deleted_at` is null and `content_type` = 'article' and `posts`.`deleted_at` is null order by RAND() limit 7
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      • app/Http/Controllers/WebController.php:739
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      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • CategoryHealtTopics.php#11aicare_prod_new1.4msselect * from `categories` where (`slug` != 'penyakit-a-z' and `slug` != 'obat-a-z' and `slug` != 'pemeriksaan-a-z' and `parent_id` = '0') and `categories`.`deleted_at` is null order by `order` asc
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      Backtrace
      • app/Repositories/Categories/CategoryHealtTopics.php:11
      • app/Http/Controllers/WebController.php:740
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • WebController.php#748aicare_prod_new1.94msselect `healthpedia`.*, `healthpedia_post`.`post_id` as `pivot_post_id`, `healthpedia_post`.`healthpedia_id` as `pivot_healthpedia_id`, `healthpedia_post`.`created_at` as `pivot_created_at`, `healthpedia_post`.`updated_at` as `pivot_updated_at` from `healthpedia` inner join `healthpedia_post` on `healthpedia`.`id` = `healthpedia_post`.`healthpedia_id` where `healthpedia_post`.`post_id` = 3005 and `healthpedia`.`deleted_at` is null
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      • app/Http/Controllers/WebController.php:748
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#751aicare_prod_new880μsselect * from `categories` where `categories`.`id` = 8 and `categories`.`deleted_at` is null limit 1
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      • app/Http/Controllers/WebController.php:751
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#779aicare_prod_new8.12msupdate `posts` set `views_count` = 1716 where `id` = 3005
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      Backtrace
      • app/Http/Controllers/WebController.php:779
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • ActivityLogger.php#174aicare_prod_new5.72msinsert into `activity_log` (`log_name`, `properties`, `batch_uuid`, `event`, `subject_id`, `subject_type`, `description`, `updated_at`, `created_at`) values ('default', '[]', null, 'updated', 3005, 'App\\Models\\Admin\\Post', 'updated', '2025-04-23 05:22:37', '2025-04-23 05:22:37')
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      • 4: 3005
      • 5: App\Models\Admin\Post
      • 6: updated
      • 7: 2025-04-23 05:22:37
      • 8: 2025-04-23 05:22:37
      Backtrace
      • vendor/spatie/laravel-activitylog/src/ActivityLogger.php:174
      • vendor/spatie/laravel-activitylog/src/Traits/LogsActivity.php:88
      • app/Http/Controllers/WebController.php:779
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • single-post-healthpedia.blade.php#37aicare_prod_new1.14msselect * from `users` where `users`.`id` = 34 limit 1
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      • view::web.v2.single-post-healthpedia:37
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new10.68msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4630 and `categories`.`deleted_at` is null
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