Aliskiren Fumarate

Aliskiren Fumarate

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Beberapa merk dagang yang mengandung aliskiren fumarete di Indonesia hingga saat ini adalah Rasilez dan Rasilamlo.

 

Cara Kerja

Aliskiren fumarate merupakan obat yang biasa dimanfaatkan untuk menurunkan tekanan darah pada pasien hipertensi atau tekanan darah tinggi. Aliskiren fumarate bekerja dengan cara menghambat enzim renin yang diproduksi ginjal, berperan dalam pengaturan tekanan darah sehingga tekanan darah dapat menjadi normal terkendali.

 

Indikasi

Obat ini digunakan di kondisi medis berupa hipertensi (tekanan darah tinggi).

 

Kontraindikasi

Kontraindikasi penggunaan aliskiren fumarat adalah:

  • Riwayat hipersensitivitas atau alergi terhadap aliskiren fumarate
  • Riwayat angioedema
  • Gagal ginjal berat
  • Obat ini tidak boleh dikonsumsi bersamaan dengan obat-obatan seperti:
    • Antijamur golongan azol
    • Obat penekan kekebalan tubuh siklosporin
    • Kuinidin untuk mengatasi detak jantung yang tidak teratur
  • Ibu hamil

 

Efek Samping

Efek samping umumnya jarang terjadi. Meskipun demikian, ada beberapa efek samping yang mungkin terjadi, yaitu:

  • Diare
  • Sakit perut
  • Sakit kepala
  • Pusing berputar
  • Mudah lelah
  • Sakit punggung
  • Batuk
  • Kejang
  • Bercak merah di kulit
  • Batu ginjal
  • Peningkatan kadar kalium di dalam darah (hiperkalemia)
  • Penurunan kadar sel darah merah (anemia)

 

Sediaan

Beberapa sediaan aliskiren fumarate yang dapat ditemukan hingga saat ini adalah tablet 150 mg dan 300 mg.

 

Dosis

Dosis dewasa: usia > 18 tahun: 150 mg, sekali sehari, dosis dapat dinaikkan hingga 300 mg, sekali sehari bila diperlukan.

 

Keamanan

Kehamilan:

Termasuk FDA kategori D (terdapat bukti positif bahwa obat ini berisiko pada janin berdasarkan data reaksi simpang dari pengalaman investigasional, pasaran, atau penelitian pada manusia), sehingga disarankan untuk tidak mengonsumsi obat tersebut.

 

Interaksi Obat

Obat-obatan penurun darah tinggi golongan ACE-inhibitor (kaptopril)

Penggunaan obat aliskiren fumarate bersamaan dengan kaptopril memiliki potensi interaksi obat berupa:

  • Risiko kejadian kerusakan ginjal
  • Hipotensi atau penurunan tekanan darah
  • Hiperkalemia yang lebih tinggi sehingga berbahaya bila dikombinasikan bersamaan. Oleh karena itu, perlu dikonsultasikan lebih lanjut apabila ada penggunaan obat yang bersamaan dengan aliskiren fumarate.

Obat-obatan antijamur golongan azol (ketoconazole, itrakonazole)

Penggunaan aliskiren fumarate bersamaan dengan antijamur golongan azol berpotensi untuk meningkatkan kadar aliskiren fumarate di dalam darah, sehingga risiko terjadinya efek samping menjadi lebih tinggi. Oleh karena itu, perlu dikonsultasikan lebih lanjut bila antijamur dikonsumsi bersamaan dengan aliskiren fumarate.

 

Writer : dr Apri Haryono Hafid
Editor :
  • dr Hanifa Rahma
Last Updated : Selasa, 8 Maret 2022 | 08:36

Badan Pengawas Obat dan Makanan. Aliskiren. Retrieved 7 March 2022, from: https://pionas.pom.go.id/monografi/aliskiren

Medscape. Aliskiren. Retrieved 7 March 2022, from: https://reference.medscape.com/drug/tekturna-aliskiren-342329

Mims Indonesia. Aliskiren fumarate. Retrieved 7 March 2022, from: https://www.mims.com/indonesia/drug/info/aliskiren%20fumarate?mtype=generic

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      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
      • 0: 5132
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.86msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4324 and `categories`.`deleted_at` is null
      Bindings
      • 0: 4324
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.01msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 2276 and `categories`.`deleted_at` is null
      Bindings
      • 0: 2276
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new5.53msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 6658 and `categories`.`deleted_at` is null
      Bindings
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      Hints
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      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
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      Hints
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      Backtrace
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      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
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      Hints
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      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
      • 0: 6520
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new5.1msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4407 and `categories`.`deleted_at` is null
      Bindings
      • 0: 4407
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
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      Backtrace
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      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
      • Use SELECT * only if you need all columns from table
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      Backtrace
      • view::layouts.v2.web_layout:547
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Backtrace
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      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
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      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    App\Models\Admin\Post
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    App\Models\Admin\Category
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