Lactulose

Lactulose
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Other Brands/Names

Laxalosan, Laxadilac, Lacons, Lactulose, Duphalac, Constuloz, Constipen, Extralac, Dynalax, Starlax, Solac, Lantulos, Dulcolactol, Lactofid, Lactulax, Pralax, Graphalac, Opilax, Constipen.

 

How It Works

Lactulose is a laxative that helps to relieve constipation. Lactulose is a synthetic disaccharide, a complex sugar, that lowers ammonia production in the intestines and promotes bowel movements.

 

Indications

Used for medical conditions such as constipation or difficulty defecating (constipation), and decreased consciousness due to liver disease (hepatic encephalopathy).

 

Contraindications

Avoid using this drug if you have medical conditions such as galactosemia, intestinal obstruction (blockage of the intestinal tract), or intestinal perforation (a hole in the intestinal wall).

 

Side Effects

Nausea, vomiting, bloating, abdominal discomfort, stomach pain, diarrhea, and allergic reactions may occur.

 

Types

3.335 grams/5 mL - 45 mL, 60 mL, 100 mL, 120 mL, and 200 mL syrups.

 

Dosage

Purpose: To treat constipation

Adult dosage: 15-45 mL (3.335 grams/5 mL) as a single dose or split into two doses per day, with the dose adjusted based on response.

Children's dosage:

  • Under 1 year: 5 mL (3.335 grams/5 mL) per day, given once daily or split into two doses.

  • 1–6 years: 5–10 mL per day, administered as a single dose or divided into two doses.

  • 7–14 years: 15 mL per day, taken as one dose or divided into two doses.

  • Over 14 years: adult dosing, given once daily or divided into two doses.

Purpose: To treat hepatic encephalopathy

Adult dosage: 30-45 mL (3.335 grams/5 mL), 3-4 times daily.

 

Safety

Pregnancy:

This product is grouped as FDA Category B drug. Animal studies have not shown fetal harm, and there are no adequate, well-controlled studies in pregnant women, so use may be considered and is likely safe for pregnant women.

 

Drug Interactions

Thiazide blood pressure-lowering medications such as hydrochlorothiazide.

Concurrent use may increase the risk of potassium ion loss from the body.

 

Looking for more information about other drugs? Click here!

 

Writer : dr Apri Haryono Hafid
Editor :
  • dr Hanifa Rahma
Last Updated : Sunday, 2 November 2025 | 15:48

Badan Pengawas Obat dan Makanan. Lactulose. Available from: https://cekbpom.pom.go.id//home/produk/d3ckcvjm0s81mmo6dq5b2pgs83/all/row/100/page/1/order/4/DESC/search/5/lactulose 

Mukherjee S, John S. Lactulose. [Updated 2021 Jul 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536930/ 

Mims Indonesia. Lactulose. Available from: https://www.mims.com/indonesia/drug/info/lactulose?mtype=generic 

Badan Pengawas Obat dan Makanan. Lactulose. Available from: https://pionas.pom.go.id/monografi/laktulosa 

Drugs.com. Lactulose. Available from: https://www.drugs.com/pregnancy/lactulose.html