Brand

Bezalip, Bezalip Retard, Cholecaps.

How it Works

Bezafibrate is a medication widely used to reduce high cholesterol and harmful fat levels in the blood (hyperlipidemia). It works by stimulating the enzyme triglyceride lipase, which plays a role in breaking down cholesterol and fat. This process lowers bad cholesterol (LDL) while increasing good cholesterol (HDL) in the bloodstream.

Indications

Bezafibrate is prescribed for medical conditions such as hyperlipidemia (elevated cholesterol or high levels of unhealthy fats in the blood).

Contraindications

Bezafibrate should not be used in patients with:

• A history of hypersensitivity or allergy to bezafibrate

• Gallbladder disease

• Low albumin protein levels in the blood (hypoalbuminemia)

• Severe liver or kidney disorders

• Pregnancy or breastfeeding

Side Effects

Although side effects are uncommon, some patients may experience:

• Loss of appetite

• Nausea or vomiting

• Headache

• Dizziness

• Weakness

• Skin reactions such as red spots, itching, or hives

• Impotence

• Anemia

• Abdominal pain

• Depression

• Insomnia

• Constipation

• Diarrhea

• Muscle pain

• Acute kidney failure

• Rare but serious skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis

Types

Bezafibrate is available in the following forms:

• 200 mg film-coated tablets

• 400 mg tablets

• 200 mg capsules

Dosage

Purpose: to treat hyperlipidemia

Adults dosage: 200 mg three times daily.

Depending on gastrointestinal tolerance, the dose may be adjusted after 5–7 days to a maintenance dose of 200 mg twice daily. Tablets should be taken immediately after meals.

Safety

Pregnancy:

Bezafibrate is classified as FDA Category N, meaning its potential effects on the fetus are not yet fully known. Pregnant women should only take this medicine under medical supervision.

Drug Interactions

Cholestyramine

When taken together with cholestyramine, bezafibrate absorption in the digestive tract may be reduced, lowering its effectiveness. If both drugs are prescribed, they must be taken under close medical monitoring.

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