Dry mouth can be caused by a variety of factors, some medications can have side effects to cause dry mouth. This condition can make it difficult to chew, swallow, and may cause general mouth discomfort. If dry mouth becomes bothersome and interferes with daily activities, it’s important to consult a doctor to explore alternative treatment options.
Types of Medications That Cause Dry Mouth
Antibiotics
Antibiotics are designed to eliminate bacteria that caused infections. However, certain antibiotics can cause dry mouth as side effects due to their anticholinergic properties. These drugs can interfere with the production of saliva, tears, and mucus.
Antidepressants
Antidepressants are commonly prescribed for mood disorders but can lead to side effects such as nausea, weight gain, and dry mouth. Some antidepressants, including citalopram, venlafaxine, duloxetine, and tricyclic antidepressants like amitriptyline or nortriptyline, have anticholinergic effects that may cause dry lips.
To ease dry mouth as a side effect of antidepressants, try drinking more water, sucking on ice cubes, brushing your teeth regularly, flossing, cutting back on caffeine beverages, and quit smoking.
Antipsychotics and Mood Stabilizers
Aside from antidepressants, other types of medications for psychiatric conditions such as antipsychotics and mood stabilizers can also reduce saliva production, leading to dry mouth. Some antipsychotics that may cause this side effect include:
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Haloperidol
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Chlorpromazine
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Fluphenazine
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Olanzapine
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Risperidone
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Lithium (Lithobid)
Benzodiazepines
Benzodiazepines, often prescribed to treat anxiety, have anticholinergic properties that can result in dry mouth. Common benzodiazepines that may trigger this side effect include alprazolam, lorazepam, diazepam, and temazepam.
Antihistamines
Antihistamines are used to relieve allergy symptoms such as runny nose or eye redness. Some antihistamines have antimuscarinic effects, that block the action of neurotransmitters in the parasympathetic nervous system, leading to decreased saliva production and dry mouth.
Diarrhea Medications
Certain medications used to treat diarrhea contain anticholinergic properties that help reduce smooth muscle contractions and alleviate diarrhea-related spasms. These medications can also cause dry mouth, and the same effect can be seen with medications for GERD (gastroesophageal reflux disease).
Stimulants
Medications used to treat ADHD, such as amphetamine salts and methylphenidate, are known to cause dry mouth. Although the exact reason for this side effect is unclear, it is believed that stimulants may activate the sympathetic nervous system, leading to reduced saliva production and, consequently, dry mouth.
Diuretics
Diuretics help to remove excess water and salt from the body by promoting urination. This reduction in body fluid levels can also affect salivary glands, leading to less saliva production and dry mouth.
How to Treat Dry Mouth As A Side Effect of Certain Medications
If a medication is causing dry mouth and it’s affecting your daily life, it's important to talk to your doctor. They may suggest solutions such as:
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Stopping the medication that cause it or switching to another treatment.
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Adopting new oral care habits like rinsing with cold water, using mouthwash, sucking on ice cubes, or chewing gum.
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Modifying your diet by avoiding salty, sour, or dry foods.
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Drinking more water throughout the day.
Some medications can reduce saliva production, leading to dry mouth. If you’re struggling with this condition, it’s worth speaking to your doctor. You can also access the consultation feature on the Ai Care app, available for download from the App Store or Play Store.
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- dr Hanifa Rahma
McGorry. A. (2021). 10 Medications That Cause Dry Mouth. Available from: https://resources.healthgrades.com/right-care/oral-health/10-medications-that-cause-dry-mouth
Mudock, J. (2024). Is Your Medication Causing Dry Mouth?. Available from: https://www.goodrx.com/drugs/side-effects/dry-mouth-are-your-medications-to-blame
Drugs. (2024). What medications cause dry mouth?. Available from: https://www.drugs.com/medical-answers/medications-dry-mouth-3566421/
Mayo Clinic. Antidepressants: Get tips to cope with side effects. Available from: https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20049305