Defisiensi Vitamin E

Defisiensi Vitamin E
Vitamin E merupakan salah satu vitamin yang dapat laruta dalam lemak dan banyak ditemukan dalam makanan dan minuman.

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Definisi

Vitamin E merupakan salah satu vitamin yang dapat larut dalam lemak dan banyak ditemukan dalam makanan dan minuman. Di dalam tubuh, vitamin E berfungsi sebagai antioksidan yang berfungsi dalam melindungi sel dari kerusakan yang disebabkan oleh radikal bebas. Radikal bebas merupakan komponen yang terbentuk ketika tubuh memproses makanan yang dikonsumsi menjadi energi.

Selain itu, radikal bebas didapat dari paparan lingkungan seperti asap rokok, polusi udara dan sinar ultraviolet dari matahari. Tubuh juga membutuhkan vitamin E untuk meningkatkan sistem imunitas tubuh sehingga dapat melawan dari serangan bakteri dan virus. Selain itu, vitamin E juga membantu melebarkan pembuluh darah dan menjaga aliran darah dari pembekuan darah.

Vitamin E sendiri memiliki 8 bentuk, yaitu alfa, beta, gamma, delta tokoferol dan alfa, beta, gama dan delta tokotrienol. Bentuk vitamin E yang dibutuhkan manusia yaitu alfa tokoferol. Semua bentuk vitamin E diserap di dalam saluran cerna lalu hanya alfa tokoferol yang dimetabolisme oleh organ hati. Selanjutnya, hati akan menghilangkan dan mengeluarkan sisa dari vitamin E. Defisiensi vitamin E sangatlah jarang dan langka terjadi pada manusia dan umumnya disebabkan oleh diet rendah vitamin E.

 

Penyebab

Defisiensi vitamin E dapat terjadi karena diturunkan di riwayat keluarga. Informasikan pada dokter bila Anda memiliki riwayat keluarga seperti kekurangan vitamin E atau kondisi tertentu seperti kongenital alfa beta lipoproteinemia dan kekurangan vitamin E yang diturunkan dan merupakan hasil dari kekurangan vitamin E yang ekstrem.

Defisiensi vitamin E dapat disebabkan oleh beberapa penyakit yang dapat mengurangi absorpsi lemak. Hal ini disebabkan tubuh memerlukan lemak untuk dapat menyerap vitamin E dengan tepat. Beberapa kondisi seperti pankreatitis kronis, penyakit celiac, gangguan hati, dan sistik fibrosis.

 

Jika Anda ingin mengetahui selengkapnya mengenai pankreatitis, Anda dapat membacanya di sini: Pankreatitis - Definisi, Penyebab, Gejala, dan Pengobatannya

 

Faktor Resiko

Beberapa kondisi mengakibatkan tubuh anda tidak dapat menyerap lemak yang mencukupi, meliputi nutrisi yang dapat larut dalam lemak termasuk vitamin E. Beberapa penyakit yang dapat menyebabkan defisiensi vitamin E seperti pankreatitis kronis, kolestasis, fibrosis sistik, sirosis hati (hepatis) pada pembuluh darah primer, penyakit Chron, sindrom short bowel.

Pada beberapa kasus, difisiensi vitamin E disebabkan oleh kondisi genetik yang disebabkan oleh ataxia. Pada bayi prematur, memiliki lemak yang lebih sedikit sehingga memiliki saluran cerna yang belum sempurna sehingga dapat menganggu proses penyerapan lemak dan vitamin E. Defisiensi vitamin E merupakan hal yang umum pada bayi lahir dan bayi yang lahir prematur dan memiliki berat badan rendah dan lemak rendah.

 

Baca Juga: Sirosis Hepatis - Definisi, Penyebab, Gejala, dan Pengobatannya

 

Gejala

Kekurangan dari vitamin E dapat menyebabkan kerusakan pada saraf dan otot yang dapat menyebabkan gejala berikut:

  • Mati rasa pada lengan dan kaki
  • Kehilangan kendali atas pergerakan tubuh
  • Kelemahan otot
  • Masalah pada  pandangan
  • Sistem imun melemah

Pada anak-anak, gejala dapat menunjukkan refleks yang lebih lambat, kesulitan berjalan, kehilangan korrdinasi, kehilangan arah (tidak mengetahui dimana lengan dan kaki tanpa melihat mereka) dan terjadi kelemahan otot.

 

Diagnosis

Dokter dapat memberikan diagnosis kekurangan vitamin E berdasarkan anamnesis atau wawancara medis, pemeriksaan fisik dan pemeriksaan penunjang.

Wawancara Medis

Wawancara medis merupakan sesi tanya jawab antara dokter dan pasien. Dokter akan bertanya mengenai:

  • Gejala yang dirasakan saat ini
  • Riwayat penyakit dahulu
  • Riwayat penyakit keluarga

 

Pemeriksaan Fisik

Pada pemeriksaan fisik, dokter akan menilai tekanan darah, laju pernapasan, denyut nadi dan suhu tubuh.

 

Pemeriksaan Penunjang

Pemeriksaan darah dilakukan untuk mengukur kadar vitamin E di dalam darah untuk mengonfirmasi diagnosis.

 

Tata Laksana

Dokter akan memberikan perawatan dari kekurangan vitamin E bila dokter sudah memastikan Anda kekurangan vitamin E. Suplemen tambahan yang diberikan oleh dokter mungkin dapat memberikan komplikasi sehingga terapi terbaik dengan mengkonsumsi makanan kaya vitamin E.

Namun, beberapa orang tubuhnya tidak dapat menghasilkan vitamin E nya sendiri sehingga perlu mendapatkannya dari luar seperti diet dan supplemen.

  • Diet
    • Anda dapat menemukan vitamin E di dalam makanan berikut:
      • Kacang dan biji-bijian seperti almon, biji matahari, kacang dan mentega kacang
      • Biji utuh
      • Minyak sayur, terutama olive oil dan sunflower oil
      • Sayuran berdaun seperti bayam, paprika merah
      • Telur
      • Sereal yang diperkaya vitamin
      • Kiwi
      • Mangga
      • Alpukat
      • Labu
  • Suplemen
    • Suplemen sering menjadi opsi efektif. Mengonsumsi supplemen menjadi salah satu cara populer untuk menambahkan vitamin dan mineral dalam diet Anda. Beberapa obat dapat memengaruhi penyerapan vitamin E, seperti antikoagulan, antiplatelet, simvastatin, niasin, obat kemoterapi, obat radioterapi.

 

Baca Juga: Vitamin E - Cara Kerja, Kontraindikasi dan Interaksi Obat

 

Komplikasi

Defisiensi vitamin E dapat menyebabkan komplikasi dari interaksi beberapa obat seperti antikoagulan dan antiplatelet sehingga dapat menyebabkan vitamin E menghambat pembekuan darah dan mengganggu faktor pembekuan darah dari vitamin E sehingga meningkatkan risiko dari pendarahan.

Komplikasi dari obat simvastatin dan niasin dapat menurunkan jumlah dari HDL dimana berlawanan dengan efek yang diharapkan setelah mengkonsumsi simvastatin dan atau niasin.

Beberapa komplikasi lain terkait dengan defisiensi vitamin E, seperti:

  • Kelemahan otot. Vitamin E merupakan hal penting (atau esensial) untuk sistem saraf pusat. Hal ini disebabkan karena vitamin E merupakan antioksidan utama dalam tubuh dan kekurangan atau defisiensi dari vitamin E dapat menyebabkan kondisi stres oksidatif yang dapat menyebabkan kelemahan otot.
  • Kesulitan berjalan dan koordinasi. Defisiensi vitamin E dapat menyebabkan saraf tertentu yang disebut dengan saraf purkinje, rusak, dan melukai kemampuan saraf untuk mengirimkan sinyal
  • Mati rasa dan kesemutan. Kerusakan pada saraf fiber dapat mencegah saraf untuk memberikan sinyal yang benar sehingga menyebabkan sensasi tertentu yang disebut dengan neuropati periperal
  • Gangguan penglihatan. Defisiensi vitamin E dapat melemahkan reseptor cahaya pada retina dan pada sel lain di mata. Hal ini dapat menyebabkan kehilangan visual atau pemandangan dari waktu ke waktu.
  • Permasalahan imunitas. Beberapa penelitian menunjukkan adanya kekurangan vitamin E dapat menghambat sistem imuniatas tubuh.
  • Anemia hemolitik. Pada orang dewasa jika terjadi defisiensi vitamin E dapat menyebabkan kerusakan sel darah merah.

Selain itu, efek samping dari konsumsi suplemen vitamin E pada pengobatan defisiensi vitamin E seperti mual, diare, kram perut, kelelahan, kelemahan, sakit kepala, gangguan penglihatan, kemerahan, difungsi gonad, peningkatan konsentrasi kreatin di urine.

 

Pencegahan

Pencegahan terbaik dari defisiensi vitamin E dengan mengkonsumsi diet sehat termasuk makanan yang mengandung vitamin E. Vitamin E dapat ditemukan pada makanan berikut:

  • Kacang dan biji-bijian seperti almon, biji matahari, kacang dan mentega kacang
  • Minyak sayur, terutama olive oil dan sunflower oil
  • Sayuran berdaun seperti bayam, paprika merah
  • Telur
  • Sereal yang diperkaya vitamin
  • Kiwi
  • Mangga
  • Alpukat
  • Labu

 

Kapan Harus ke Dokter?

Hubungi dokter bila Anda merasa ada gejala kekurangan vitamin E. Pemeriksaan rutin perlu dilakukan dengan dokter untuk menjaga kebutuhan vitamin E Anda. Dokter akan menentukan tindakan yang diperlukan untuk defisiensi vitamin E.

 

Mau tahu informasi seputar penyakit lainnya? Cek di sini, ya!

 

 

Writer : dr Kevin Luke
Editor :
  • dr. Monica Salim
Last Updated : Kamis, 7 Maret 2024 | 06:17

Vitamin E. (2021). Retrieved 13 February 2023, from https://ods.od.nih.gov/factsheets/VitaminE-Consumer/#:

Vitamin E Deficiency. (2022). Retrieved 13 February 2023, from https://www.ncbi.nlm.nih.gov/books/NBK519051/

Vitamin E Deficiency. (2022). Retrieved 13 February 2023, from https://www.msdmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-e-deficiency

What are the Symptoms of Low Vitamin E?. (2018). Retrieved 13 February 2023, from https://www.medicalnewstoday.com/articles/321800

How to Identify and Treat a Vitamin E Deficiency. (2018). Retrieved 13 February 2023, from https://www.healthline.com/health/food-nutrition/vitamin-e-deficiency

Vitamin E. (2023). Retrieved 13 February 2023, from https://www.hsph.harvard.edu/nutritionsource/vitamin-e/

Vitamin E. (2020). Retrieved 13 February 2023, from https://www.mayoclinic.org/drugs-supplements-vitamin-e/art-20364144

Vitamin E Deficiency. (2021). Retrieved 13 February 2023, from https://emedicine.medscape.com/article/126187-overview

Vitamin E (2021). Retrieved February 13, 2023, from https://medlineplus.gov/ency/article/002406.htm

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      • Use SELECT * only if you need all columns from table
      Backtrace
      • app/Http/Controllers/WebController.php:748
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#751aicare_prod_new1.06msselect * from `categories` where `categories`.`id` = 7 and `categories`.`deleted_at` is null limit 1
      Bindings
      • 0: 7
      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • app/Http/Controllers/WebController.php:751
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#779aicare_prod_new8.04msupdate `posts` set `views_count` = 802 where `id` = 6475
      Bindings
      • 0: 802
      • 1: 6475
      Backtrace
      • app/Http/Controllers/WebController.php:779
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • ActivityLogger.php#174aicare_prod_new6.34msinsert into `activity_log` (`log_name`, `properties`, `batch_uuid`, `event`, `subject_id`, `subject_type`, `description`, `updated_at`, `created_at`) values ('default', '[]', null, 'updated', 6475, 'App\\Models\\Admin\\Post', 'updated', '2025-04-14 02:24:04', '2025-04-14 02:24:04')
      Bindings
      • 0: default
      • 1: []
      • 2: 
      • 3: updated
      • 4: 6475
      • 5: App\Models\Admin\Post
      • 6: updated
      • 7: 2025-04-14 02:24:04
      • 8: 2025-04-14 02:24:04
      Backtrace
      • vendor/spatie/laravel-activitylog/src/ActivityLogger.php:174
      • vendor/spatie/laravel-activitylog/src/Traits/LogsActivity.php:88
      • app/Http/Controllers/WebController.php:779
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • single-post-healthpedia.blade.php#37aicare_prod_new1.19msselect * from `users` where `users`.`id` = 43 limit 1
      Bindings
      • 0: 43
      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::web.v2.single-post-healthpedia:37
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new8.7msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 3622 and `categories`.`deleted_at` is null
      Bindings
      • 0: 3622
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new8.45msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4999 and `categories`.`deleted_at` is null
      Bindings
      • 0: 4999
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new8.37msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4280 and `categories`.`deleted_at` is null
      Bindings
      • 0: 4280
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new8.46msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 4917 and `categories`.`deleted_at` is null
      Bindings
      • 0: 4917
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new8.47msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 7495 and `categories`.`deleted_at` is null
      Bindings
      • 0: 7495
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new8.55msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 137 and `categories`.`deleted_at` is null
      Bindings
      • 0: 137
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new8.42msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 6444 and `categories`.`deleted_at` is null
      Bindings
      • 0: 6444
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new8.57msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 2592 and `categories`.`deleted_at` is null
      Bindings
      • 0: 2592
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new8.47msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 2512 and `categories`.`deleted_at` is null
      Bindings
      • 0: 2512
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new8.45msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 2419 and `categories`.`deleted_at` is null
      Bindings
      • 0: 2419
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new8.42msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 6258 and `categories`.`deleted_at` is null
      Bindings
      • 0: 6258
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • web_layout.blade.php#122aicare_prod_new1.15msselect * from `pages` where `slug` = 'about-us' limit 1
      Bindings
      • 0: about-us
      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::layouts.v2.web_layout:122
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • web_layout.blade.php#547aicare_prod_new970μsselect * from `faqs` limit 1
      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::layouts.v2.web_layout:547
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • web_layout.blade.php#551aicare_prod_new1.37msselect * from `term_policies`
      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
      Backtrace
      • view::layouts.v2.web_layout:551
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    App\Models\Admin\Post
    48Post.php#?
    App\Models\Admin\Category
    22Category.php#?
    App\User
    3User.php#?
    App\Models\Admin\Tag
    3Tag.php#?
    App\Models\TermPolicy
    3TermPolicy.php#?
    App\Models\Admin\Page
    1Page.php#?
    App\Models\Admin\Faq
    1Faq.php#?
        locale
        id
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        array:1 [ "url" => "https://ai-care.atmatech.id/kelainan-saraf/defisiensi-vitamin-e" ]
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        array:2 [ "old" => [] "new" => [] ]
        path_info
        /kelainan-saraf/defisiensi-vitamin-e
        status_code
        200
        
        status_text
        OK
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        html
        content_type
        text/html; charset=UTF-8
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        []
        
        request_request
        []
        
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        request_cookies
        0 of 0
        array:2 [ "XSRF-TOKEN" => "SfLKaum4XirB2ZjW0JiDf1NB97gi0GO6S5sOWC8T" "laravel_session" => "P7mrDZarBawg0nDR7A3XJijfe3qCfiXAeWewBehI" ]
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