Sepsis Neonatorum

Sepsis Neonatorum

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Definisi

Sepsis neonatorum adalah kondisi medis serius yang terjadi ketika bayi baru lahir (berusia kurang dari 28 hari) mengalami infeksi serius. Sepsis terjadi ketika tubuh memberikan respon yang ekstrem terhadap suatu infeksi. Pada bayi baru lahir yang mengalami infeksi dan sepsis dapat mengalami peradangan di seluruh bagian tubuh. Peradangan dan pembekuan darah menyebabkan penurunan aliran darah ke anggota gerak dan organ penting bayi. Hal ini dapat menyebabkan kegagalam organ dan bahkan kematian.

Dokter mengklasifikasikan sepsis neonatorum dalam 2 kategori berdasarkan usia terjadinya:

  • Sepsis neonatorum onset dini: sepsis yang terjadi dalam 72 jam pertama kehidupan
  • Sepsis neonatorum onset lambat: sepsis yang terjadi setelah 3 hari kehidupan

Sepsis pada bayi baru lahir dapat disembuhkan. Banyak bayi baru lahir yang mengalami sepsis sembuh sempurna dan tidak mengalami masalah lainnya. Namun, kondisi ini merupakan salah satu penyebab utama kematian bayi. Lebih cepat bayi Anda mendapatkan penanganan, lebih baik hasilnya. Risiko kematian akibat sepsis meningkat sekitar 7.6% pada setiap jam yang terlewat tanpa terapi.

 

Penyebab

Infeksi bakteri adalah penyebab sepsis neonatorum yang paling banyak. Bakteri seperti E. coli, Listeria, dan Streptococcus Grup B (GBS) adalah bakteria yang sering menyebabkan infeksi yang dapat berujung pada sepsis.

Virus, jamur, dan parasit juga dapat menyebabkan sepsis. Sebagai contoh, virus herpes simpleks (HSV) dapat menyebabkan infeksi serius pada bayi baru lahir.

Bayi baru lahir mengalami sepsis dengan cara yang berbeda berdasarkan usia saat terjadi sepsis:

  • Sepsis neonatorum onset dini. Bayi baru lahir dengan sepsis neonatorum onset dini mendapatkan infeksi dari ibunya sebelum atau saat persalinan. Infeksi ini terjadi ketika bayi terpapar jenis bakteri tertentu. Infeksi ini lebih sering terjadi ketika:
    • Bakteria seperti GBS telah mengkolonisasi vagina ibu saat kehamilan
    • Bayi lahir prematur
    • Selaput ketuban Anda pecah dini (lebih dari 18 jam sebelum bayi lahir)
    • Terdapat infeksi pada plasenta dan cairan amnion (suatu kondisi yang disebut dengan korioamnionitis)
  • Sepsis neonatorum onset lambat. Bayi baru lahir dengan sepsis neonatorum onset lambat terkena infeksi setelah persalinan. Bayi biasanya terkena infeksi dari bakteri di lingkungannya. Bakteri dapat menyebar ke bayi Anda melalui peralatan medis seperti kateter, infus dan selang. Infeksi ini lebih sering terjadi ketika bayi Anda:
    • Memiliki berat badan lahir rendah
    • Membutuhkan selang pernapasan
    • Membutuhkan antibiotik
    • Memiliki kateter yang terpasang pada pembuluh darah atau kandung kemih dalam jangka waktu yang lama
    • Membutuhkan terapi untuk kondisi lainnya yang menambah waktu tinggal di rumah sakit

 

Faktor Risiko

Sepsis neonatorum dapat terjadi pada semua bayi. Namun, bayi prematur lebih sering mengalami sepsis dibandingkan dengan bayi cukup bulan karena sistem imunnya belum cukup matang. Bayi yang lahir prematur tidak memiliki antibodi untuk melindungi mereka dari bakteri tertentu. Hal ini karena mereka lahir sebelum mereka dapat menerima antibod dari ibu.

Sepsis neonatorum juga lebih sering terjadi pada bayi yang:

  • Memiliki berat badan lahir rendah
  • Memiliki skor Apgar rendah saat lahir
  • Memiliki ibu dengan faktor risiko tertentu, seperti infeksi saat kehamilan

 

Gejala

Banyak gejala sepsis neonatorum sama dengan gejala yang akan Anda lihat ketika bayi Anda mengalami penyakit lainnya. Jika bayi Anda mengalami gejala tersebut, seringkali hal ini bukan merupakan sepsis. Namun, jika bayi baru lahir Anda memiliki lebih dari satu gejala dibawah ini atau mereka terlihat lebih sakit daripada normalnya, Anda harus mencari pertolongan medis segera.

Gejala sepsis neonatorum meliputi:

  • Demam atau suhu tubuh rendah
  • Detak jantung cepat atau lambat
  • Napas cepat atau sesak napas
  • Muntah
  • Diare
  • Penurunan atau kesulitan makan
  • Perut bengkak
  • Tangan dan kaki dingin
  • Kulit lembap dan pucat
  • Kulit dan bagian putih mata menjadi kuning (ikterus)
  • Penurunan aktivitas
  • Kejang

 

Diagnosis

Dokter akan mengevaluasi gejala bayi Anda dan menanyakan mengenai riwayat kesehatan Anda.

Dokter akan merekomendasikan pemeriksaan yang digunakan untuk mendiagnosis penyebab infeksi bayi Anda. Pemeriksaan tersebut dapat meliputi:

  • Pemeriksaan darah: hitung darah lengkap, kultur darah, dan protein C reaktif
  • Pemeriksaan urine: urinalisis dan kultur urin
  • Pungsi lumbal: dokter memasukan jarum yang sangat kecil ke dalam rongga diantara tulang belakang bayi untuk mengambil cairan tulang belakang untuk memeriksa adanya infeksi
  • Pemeriksaan radiologi: X-ray dada atau USG

 

Tata Laksana

Tata laksana sepsis neonatorum harus dimulai segera. Dokter dapat memasukan bayi Anda ke unit perawatan intensif (ICU). Terapi untuk sepsis neonatorum dapat meliputi:

  • Infus cairan
  • Infus antibiotik untuk memerangi infeksi bakteri
  • Obat antivirus untuk memerangi infeksi virus
  • Obat untuk jantung dan/atau tekanan darah
  • Pemberian bantuan oksigen atau alat bantu nafas lainnya, jika diperlukan

 

Komplikasi

Kebanyakan bayi baru lahir yang sembuh dari sepsis tidak mengalami komplikasi apapaun. Namun, banyak bayi yang bertahan mengalami masalah kesehatan jangka panjang. Lebih dari sepertiga bayi yang bertahan dari sepsis akan mengalami keterlambatan pada kemampuan kognitif.

Beberapa bayi mengalami infeksi pada membran selaput otak yang disebut dengan meningitis. Bayi baru lahir yang mengalami kondisi ini dapat mengalami gejala dan efek samping yang serius, seperti:

  • Kelesuan yang ekstrem
  • Penonjolan ubun-ubun
  • Gangguan pendengaran
  • Keterlambatan perkembangan
  • Cerebral palsy
  • Kejang
  • Koma

 

Baca Juga: Cerebral Palsy - Definisi, Penyebab, Gejala, dan Pengobatannya

 

Pencegahan

Untuk mencegah menularkan infeksi ke bayi Anda, dokter kandungan dapat merekomendasikan Anda untuk mengkonsumsi antibiotik preventif. Dokter akan memberi Anda infus antibiotik selama beberapa jam sebelum persalinan jika:

  • Anda mengalami infeksi seperti korioamnionitis
  • Anda mengalami kolonisasi strep grup B pada vagina
  • Anda pernah melahirkan bayi dengan sepsis

Selain itu, terdapat beberapa langkah yang dapat Anda lakukan untuk mencegah sepsis, seperti:

  • Mempraktikan kebersihan yang baik
  • Memeriksakan diri ke dokter dengan rutin
  • Mendapatkan vaksin yang direkomendasikan
  • Mengenali tanda sepsis
  • Mencari pertolongan medis segera jika Anda mencurigai diri Anda atau bayi Anda mengalami sepsis

 

Baca Juga: Korioamnionitis - Definisi, Penyebab, Gejala, dan Pengobatannya

 

Kapan Harus ke Dokter?

Jika Anda sudah berada di rumah dan bayi baru lahir Anda mengalami gejala sepsis dibawah ini, segera hubungi nomor emergensi atau pergi ke IGD terdekat. Anda juga dapat memantau gejala berikut:

  • Bayi Anda lebih rewel atau mengantuk daripada biasanya
  • Kulit bayi Anda dingin, pucat, atau berubah warna
  • Bayi Anda tidak buang air kecil selama lebih dari 12 jam
  • Bayi Anda tidak merespon atau mengalami kesulitan bernafas

 

Mau tahu informasi seputar penyakit lainnya? Cek di sini, ya!

 

 

Writer : dr Tea Karina Sudharso
Editor :
  • dr. Monica Salim
Last Updated : Kamis, 6 Juni 2024 | 09:29

Sepsis in newborns (neonatal sepsis): Symptoms, causes & treatment (2023) Cleveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/15371-sepsis-in-newborns (Accessed: March 10, 2023). 

Default - Stanford Medicine Children's health (no date) Stanford Medicine Children's Health - Lucile Packard Children's Hospital Stanford. Available at: https://www.stanfordchildrens.org/en/topic/default?id=sepsis-90-P02410 (Accessed: March 10, 2023). 

Tesini, B.L. (2022) Sepsis in newborns - children's health issues, MSD Manual Consumer Version. MSD Manuals. Available at: https://www.msdmanuals.com/home/children-s-health-issues/infections-in-newborns/sepsis-in-newborns (Accessed: March 10, 2023).

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      Backtrace
      • app/Repositories/Categories/CategoryHealtTopics.php:11
      • app/Http/Controllers/WebController.php:376
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • WebController.php#377aicare_prod_new102msselect * from `posts` where `status` = 1 and `publish_date` <= '2025-04-06 19:35:21' and `content_type` = 'article' and `posts`.`deleted_at` is null order by RAND() limit 7
      Bindings
      • 0: 1
      • 1: 2025-04-06 19:35:21
      • 2: article
      Hints
      • Use SELECT * only if you need all columns from table
      • ORDER BY RAND() is slow, try to avoid if you can. You can read this or this
      Backtrace
      • app/Http/Controllers/WebController.php:377
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • WebController.php#391aicare_prod_new7.54msupdate `posts` set `views_count` = 780 where `id` = 6687
      Bindings
      • 0: 780
      • 1: 6687
      Backtrace
      • app/Http/Controllers/WebController.php:391
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • vendor/laravel/framework/src/Illuminate/Routing/Route.php:205
    • ActivityLogger.php#174aicare_prod_new6.87msinsert into `activity_log` (`log_name`, `properties`, `batch_uuid`, `event`, `subject_id`, `subject_type`, `description`, `updated_at`, `created_at`) values ('default', '[]', null, 'updated', 6687, 'App\\Models\\Admin\\Post', 'updated', '2025-04-06 19:35:22', '2025-04-06 19:35:22')
      Bindings
      • 0: default
      • 1: []
      • 2: 
      • 3: updated
      • 4: 6687
      • 5: App\Models\Admin\Post
      • 6: updated
      • 7: 2025-04-06 19:35:22
      • 8: 2025-04-06 19:35:22
      Backtrace
      • vendor/spatie/laravel-activitylog/src/ActivityLogger.php:174
      • vendor/spatie/laravel-activitylog/src/Traits/LogsActivity.php:88
      • app/Http/Controllers/WebController.php:391
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • single-post-healthpedia.blade.php#37aicare_prod_new1.15msselect * from `users` where `users`.`id` = 31 limit 1
      Bindings
      • 0: 31
      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::web.v2.single-post-healthpedia:37
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new7.5msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 6144 and `categories`.`deleted_at` is null
      Bindings
      • 0: 6144
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new7.12msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 7487 and `categories`.`deleted_at` is null
      Bindings
      • 0: 7487
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new6.71msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 2173 and `categories`.`deleted_at` is null
      Bindings
      • 0: 2173
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new7.45msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 1987 and `categories`.`deleted_at` is null
      Bindings
      • 0: 1987
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new6.53msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 1854 and `categories`.`deleted_at` is null
      Bindings
      • 0: 1854
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new6.59msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 5079 and `categories`.`deleted_at` is null
      Bindings
      • 0: 5079
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new6.09msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 6456 and `categories`.`deleted_at` is null
      Bindings
      • 0: 6456
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new5.83msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 2157 and `categories`.`deleted_at` is null
      Bindings
      • 0: 2157
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new7.74msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 1916 and `categories`.`deleted_at` is null
      Bindings
      • 0: 1916
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new5.94msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 2162 and `categories`.`deleted_at` is null
      Bindings
      • 0: 2162
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new10.57msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 2089 and `categories`.`deleted_at` is null
      Bindings
      • 0: 2089
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • related-article.blade.php#8aicare_prod_new6.56msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 2093 and `categories`.`deleted_at` is null
      Bindings
      • 0: 2093
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • web_layout.blade.php#122aicare_prod_new720μsselect * from `pages` where `slug` = 'about-us' limit 1
      Bindings
      • 0: about-us
      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::layouts.v2.web_layout:122
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • web_layout.blade.php#547aicare_prod_new470μsselect * from `faqs` limit 1
      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::layouts.v2.web_layout:547
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • web_layout.blade.php#551aicare_prod_new670μsselect * from `term_policies`
      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
      Backtrace
      • view::layouts.v2.web_layout:551
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    App\Models\Admin\Post
    217Post.php#?
    App\Models\Admin\Category
    24Category.php#?
    App\User
    4User.php#?
    App\Models\Admin\Tag
    4Tag.php#?
    App\Models\TermPolicy
    3TermPolicy.php#?
    App\Models\Admin\Page
    1Page.php#?
    App\Models\Admin\Faq
    1Faq.php#?
        locale
        id
        _token
        ONtGV62LUzHJX5l0nH0YiFpOGeYPRB73hJelaNLc
        _previous
        array:1 [ "url" => "https://ai-care.atmatech.id/healthpedia-penyakit/sepsis-neonatorum" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        path_info
        /healthpedia-penyakit/sepsis-neonatorum
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:19 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "x-real-ip" => array:1 [ 0 => "3.147.49.219" ] "x-forwarded-for" => array:1 [ 0 => "3.147.49.219" ] "x-forwarded-proto" => array:1 [ 0 => "https" ] "x-forwarded-scheme" => array:1 [ 0 => "https" ] "host" => array:1 [ 0 => "ai-care.atmatech.id" ] "connection" => array:1 [ 0 => "keep-alive" ] ]
        request_cookies
        []
        
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