Other Brands/Names

Vitahealth COQ10 100 mg, Ubiquinol-COQ10, Now COQ10 100 mg, Konilife COQ10, Blackmores COQ10 75 mg.

How it Works

Coenzyme Q10 is a vitamin-like compound that is naturally present in almost all parts of the body, with the highest concentrations found in the heart, liver, kidneys, and pancreas. Small amounts of this compound are found in foods such as meat and seafood, and it can also be produced in a laboratory.

Coenzyme Q10 is essential for the proper function of many organs and chemical reactions in the body. It plays a role in providing energy to cells and also acts as an antioxidant. People with certain conditions, such as heart failure, high blood pressure, gum disease, Parkinson’s disease, blood infections, some muscle disorders, and HIV infection, may have lower levels of Coenzyme Q10.

Indications

Coenzyme Q10 is most often used for heart-related conditions, including heart failure, fluid retention in the body (congestive heart failure), chest pain (angina), and high blood pressure. It can also be used for preventing migraines, managing Parkinson’s disease, and treating various other conditions.

Contraindications

A history of allergy or hypersensitivity to Coenzyme Q10 may cause reactions such as hives, rash, itching, redness, or difficulty breathing.

Side Effects

Coenzyme Q10 is generally safe for most adults. However, mild side effects may occur, including:

• Stomach upset

• Loss of appetite

• Nausea

• Vomiting

• Diarrhea

This supplement may cause allergic skin rashes in some individuals. It can also lower blood pressure, so those with low blood pressure should monitor carefully.

Dividing the daily dose into smaller amounts taken two or three times per day instead of a single large dose may help reduce the risk of side effects.

Types

In Indonesia, Coenzyme Q10 is available in softgel capsule form in the following strengths:

• 30 mg

• 50 mg

• 60 mg

• 75 mg

• 100 mg

• 150 mg

• 200 mg

Dosage

The usual dose is 1–3 softgel capsules daily. The typical amount taken is around 100–200 mg per day. Always read the instructions on the product label carefully or consult your doctor before use.

Safety

Pregnancy and Breastfeeding

Coenzyme Q10 is considered likely safe when used appropriately during pregnancy. Studies have shown it to be safe when taken twice daily starting from 20 weeks of pregnancy until delivery. However, its safety during breastfeeding is not well known; consult your doctor before use.

Children 

Coenzyme Q10 is likely safe for children when taken by mouth but should only be used under medical supervision.

Drug Interactions

• Coenzyme Q10 and Cancer Medications (alkylating agents)

Because Coenzyme Q10 is an antioxidant, there is concern that it may reduce the effectiveness of certain chemotherapy drugs. Examples of these treatments include busulfan, carboplatin, cisplatin, cyclophosphamide (Cytoxan), dacarbazine, thiotepa, and others.

• Coenzyme Q10 and High Blood Pressure Medications

Coenzyme Q10 may lower blood pressure. Taking it together with blood pressure–lowering drugs could cause blood pressure to fall too low (hypotension). Examples include captopril, enalapril, losartan, valsartan, diltiazem, amlodipine, hydrochlorothiazide, furosemide, and others.

• Coenzyme Q10 and Warfarin

Warfarin works by slowing blood clotting, while Coenzyme Q10 may promote clotting. This can make warfarin less effective and raise the risk of blood clots. Regular blood monitoring is necessary, and warfarin dosage adjustments may be required. Consult your doctor before combining these medications.

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