Anti Toksoplasma Aviditas IgG

Anti Toksoplasma Aviditas IgG
Toxoplasmosis yang terjadi pada ibu hamil dapat ditularkan dari ibu kepada janin melalui plasenta

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Definisi

Toksoplasmosis merupakan infeksi yang disebabkan oleh parasit Toksoplasma gondii. Toksoplasmosis sendiri dapat ditemukan pada manusia dan berbagai jenis burung atau hewan, diantaranya kucing yang diketahui sebagai salah satu pembawa parasit Toksoplasma gondii. Penyebaran dari Toksoplasmosis dapat menyebar melalui berbagai cara seperti kotoran kucing, transfusi darah atau transplantasi organ atau jaringan tubuh, konsumsi makanan dari tanah yang terkontaminasi, serta konsumsi daging (kambing, sapi, dan babi) mentah atau setengah matang.

Toksoplasmosis yang terjadi pada ibu hamil dapat ditularkan dari ibu kepada janin melalui plasenta sehingga mengakibatkan bayi prematur, toksoplasmosis kongenital, hingga mengakibatkan keguguran. Toksoplasmosis kongenital ditandai dengan adanya kerusakan pada organ mata, sistem saraf pusat, kulit dan telinga, dimana kerusakan tersebut tidak jarang akan muncul ketika anak berusia remaja atau pun dewasa.

Ketika terjadi infeksi, tubuh akan memproduksi IgM yang dapat terukur dalam darah hingga 2 minggu paparan. Namun, beberapa bulan kemudian, IgM tidak dapat terdeteksi dan tergantikan dengan IgG. IgM dapat muncul kembali ketika infeksi terjadi kembali. Antibodi IgG merupakan antibodi yang muncul setelah IgM dan dapat menetap seumur hidup.

Pemeriksaan Anti Toksoplasma Aviditas IgG merupakan pemeriksaan yang mengukur kekuatan ikatan antara antibodi IgG dengan virus toksoplasma sehingga dapat membedakan infeksi utama (primer) dari infeksi di masa lalu atau pernah terinfeksi sebelumnya. Hal ini disebabkan setelah terjadi infeksi toksoplasma primer, kekuatan ikatan antibodi IgG tersebut memiliki kekuatan ikatan yang rendah, lalu setelah 2 sampai 4 bulan pematangan akan memiliki kekuatan ikatan yang tinggi.

 

Indikasi

Pemeriksaan anti toksoplasma aviditas IgG diperlukan bila ada indikasi dugaan terjadi infeksi toksoplasma pada ibu hamil (ditandai dengan nilai pemeriksaan toksoplasma IgG dan IgM yang positif) untuk memperkirakan kapan infeksi terjadi. Selain itu, pemeriksaan ini dilakukan untuk menentukan riwayat seseorang telah terinfeksi toksoplasma atau membantu menentukan suatu komplikasi yang disebabkan oleh infeksi dari toksoplasma aktif.

 

Kontraindikasi

Pemeriksaan Anti Toksoplasma aviditas IgG dapat dianggap aman dan risiko terkait sedang. Pemeriksaan Anti Toksoplasma IgG tidak memiliki kontraindikasi khusus. Bila Anda sudah mengambil sampel darah, pemeriksaan ini serupa dengan pengambilan sampel tersebut.

 

Persiapan Sebelum Pemeriksaan

Tidak ada persiapan khusus sebelum melakukan pemeriksaan Anti Toksoplasma IgG. Anda dapat berkonsultasi dengan dokter terkait obat-obatan yang Anda konsumsi sebelum pengujian. Pemeriksaan ini tidak mewajibkan Anda puasa sebelumnya.

 

Prosedur Pemeriksaan

Pemeriksaan Anti Toksoplasma IgG menggunakan sampel darah dan sangat sederhana. Petugas laboratorium akan membersihkan lengan Anda dengan alcohol steril dan mengambil sedikit darah Anda dari pembuluh darah vena di lengan menggunakan spuit steril. Pada bayi, pengambilan darah dilakukan pada tumit. Selanjutnya, darah akan dimasukan ke dalam tabung darah dan diperiksa oleh petugas laboratorium pada mesin khusus. Risiko pemeriksaan dalam darah sangat kecil. Beberapa orang merasakan nyeri, pusing, dan memar saat pengambilan darah. Namun, hal ini biasanya hilang dengan cepat.

 

Nilai Normal dan Abnormal

Nilai ikatan antara antibodi IgG dengan virus memiliki nilai normal yang tinggi dan nilai abnormal yang rendah. Hal ini dapat dinilai dengan nilai indeks aviditas. Bila memiliki nilai <0.50 atau 50%, hal ini dapat diartikan sebagai memiliki ikatan yang rendah sedangkan nilai >0.60 atau 60% dapat diartikan sebagai memiliki ikatan yang tinggi. Bila nilai pemeriksaan diantara 0.50 dan 0.60 atau 50% < nilai pemeriksaan < 60%, hal ini menandakan nilai batas pada masa yang tidak dapat ditentukan (kondisi virus belum aktif).

 

Hasil dan Saran (Pemeriksaan Lanjutan)

Hasil pemeriksaan dapat bervariasi tergantung pada usia, jenis kelamin, riwayat kesehatan dan metode pengujian yang digunakan. Hasil pemeriksaan  Anti Toksoplasma Aviditas IgG tidak dapat dibaca sebagai satu hasil, sehingga diperlukan pemeriksaan lain seperti pemeriksaan anti toksoplasma aviditas IgM untuk memastikan kembali diagnosis yang akan ditegakkan oleh dokter.

Pada pasien dengan nilai ikatan antibodi yang  rendah, yaitu < 0.50 memiliki arti baru saja terinfeksi oleh virus toksoplasma dalam rentang waktu 3 bulan terakhir, sedangkan pada pasien dengan nilai ikatan antibodi yang tinggi, yaitu >0.60 dapat diartikan infeksi dari toksoplasma tersebut didapatkan sebelum 3 bulan terakhir.

Pada hasil pemeriksaan antara 0.50 hingga 0.60, dokter akan menyarankan melakukan pemeriksaan tambahan atau pemeriksaan lainnya atau menunggu pada periode tertentu karena pada waktu tersebut, infeksi toksoplasma dalam periode waktu yang tidak dapat ditentukan (belum aktif).

 

Konsultasikan ke Dokter yang Tepat

Bila hasil pemeriksaan anti toksoplasma aviditas IgG Anda tidak normal, Anda dapat berkonsultasi dengan dokter umum untuk mendapatkan diagnosis dan terapi yang sesuai. Hal ini dapat disebabkan oleh faktor lainnya seperti obat-obatan, gaya hidup atau diet dan kondisi kesehatan tertentu (seperti kehamilan) yang mempengaruhi kadar progesteron.

Dokter akan menyarankan pemeriksaan lebih lanjut terkait pemeriksaan lanjutan yang dilakukan. Bila diperlukan, Anda juga dapat berkonsultasi dengan dokter spesialis penyakit dalam terkait kondisi Anda. Dokter juga akan melakukan pengawasan terhadap terapi yang diberikan dan efektivitas dari terapi yang diberikan. Informasikan pada dokter terkait gejala yang Anda rasakan.

 

Mau tahu informasi seputar hasil pemeriksaan laboratorium, radiologi, dan lainnya? Cek di sini, ya!

 

 

Writer : dr Kevin Luke
Editor :
  • dr. Monica Salim
Last Updated : Selasa, 14 Mei 2024 | 05:47

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Toxoplasmosis Test. (2021). Retrieved 11 July 2023, from https://www.healthline.com/health/toxoplasma-test

How Toxoplasmosis is Diagnosed. (2021). Retrieved 11 July 2023, from https://www.verywellhealth.com/toxoplasmosis-diagnosis-4164712

Toxoplasmosis IgG and IgM. (2022). Retrieved 11 July 2023, from https://www.biron.com/en/glossary/toxoplasmosis-igg-and-igm/

Toxoplasma Blood Test. (2022). Retrieved 11 July 2023, from https://medlineplus.gov/ency/article/003514.htm

Role of Toxoplasma gondii IgG Avinity Testing in Discriminating between Acute and Chronic Toxoplasmosis in Pregnancy. (2020). Retrieved 11 July 2023, from https://journals.asm.org/doi/10.1128/jcm.00505-20

IgG Avinity ELISA Test for Diagnosis of Acute Toxoplasmosis in Humans. (2012). Retrieved 11 July 2023, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375462/#:~:text=High%20avidity%20(AI%E2%89%A560,within%20the%20last%203%20months. 

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      • vendor/spatie/laravel-activitylog/src/Traits/LogsActivity.php:88
      • app/Http/Controllers/WebController.php:779
      • vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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      Bindings
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      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::web.v2.single-post-healthpedia:37
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new8.09msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 8466 and `categories`.`deleted_at` is null
      Bindings
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      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new7.88msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 3891 and `categories`.`deleted_at` is null
      Bindings
      • 0: 3891
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new7.51msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 6361 and `categories`.`deleted_at` is null
      Bindings
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      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new7.77msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 7165 and `categories`.`deleted_at` is null
      Bindings
      • 0: 7165
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new7.43msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 3643 and `categories`.`deleted_at` is null
      Bindings
      • 0: 3643
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new7.44msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 9630 and `categories`.`deleted_at` is null
      Bindings
      • 0: 9630
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
    • article-popular.blade.php#8aicare_prod_new7.34msselect `categories`.*, `category_post`.`post_id` as `pivot_post_id`, `category_post`.`category_id` as `pivot_category_id`, `category_post`.`created_at` as `pivot_created_at`, `category_post`.`updated_at` as `pivot_updated_at` from `categories` inner join `category_post` on `categories`.`id` = `category_post`.`category_id` where `category_post`.`post_id` = 941 and `categories`.`deleted_at` is null
      Bindings
      • 0: 941
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.article-popular:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::web.v2.partials.article-popular:11
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
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      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
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      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
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      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
      • 0: 7190
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Bindings
      • 0: 6777
      Hints
      • Use SELECT * only if you need all columns from table
      Backtrace
      • view::web.v2.partials.related-article:8
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
      • Use SELECT * only if you need all columns from table
      • LIMIT without ORDER BY causes non-deterministic results, depending on the query execution plan
      Backtrace
      • view::layouts.v2.web_layout:122
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
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      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
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      Backtrace
      • view::layouts.v2.web_layout:547
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
      • vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:72
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      Hints
      • Use SELECT * only if you need all columns from table
      • The SELECT statement has no WHERE clause and could examine many more rows than intended
      Backtrace
      • view::layouts.v2.web_layout:551
      • vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • vendor/livewire/livewire/src/Mechanisms/ExtendBlade/ExtendedCompilerEngine.php:22
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    App\Models\Admin\Category
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