Other Brands/Names

Borteloma, Velcade, Cytomib, Fonkozomib, Tezobell, Bortero, Teoxib.

How It Works

Bortezomib is an antineoplastic (anticancer) agent used in oncology therapy. It works by destroying malignant cells.

Indications

Bortezomib is indicated for multiple myeloma (a malignancy of the bone marrow). It is also used for mantle cell lymphoma, a rapidly growing cancer that begins in immune system cells.

Contraindication

This medicine must not be used in patients with:

• A history of allergy or hypersensitivity to bortezomib

• Pregnancy: use effective contraception to prevent pregnancy during bortezomib treatment and for at least 7 months after the last dose (consult your doctor to choose an appropriate method)

• Breastfeeding: do not breastfeed while receiving bortezomib and for 2 months after the final dose

Side Effects

Side effects of bortezomib may occur, including:

• Dizziness

• Nausea

• Vomiting

• Loss of appetite

• Diarrhea

• Constipation

• Fatigue

• Weakness

• Pain or redness at the injection site

• Signs of kidney problems may include:
  

  • Painful urination

  • Pink or bloody urine

  • Noticeable changes in the amount of urine

• Muscle cramps

• May also affect blood cells

Types

Bortezomib is supplied as a 3.5 mg vial of powder for injection.

Dosage

This medicine is administered by intravenous injection. Depending on the drugs used in combination, the dosing cycle can differ. Each cycle includes dosing followed by a 10-day rest period, with one cycle spanning 3 weeks. Dose reductions or adjustments may be required based on safety considerations or patient tolerance.

Safety

This medicine can cause dizziness. Do not drive, operate machinery, or perform tasks requiring alertness until you can do so safely. Bortezomib may raise your risk of infections or worsen existing ones. Avoid contact with people who have contagious illnesses such as chickenpox, measles, or influenza. Inform your healthcare professional that you are receiving bortezomib before any immunizations/vaccinations.

Drug Interactions

Other medicines can alter how bortezomib is cleared from the body when used at the same time and may change its effects, such as:

• Rifamycin antibiotics

• Antiseizure medicines such as carbamazepine or phenytoin

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