Other Brands/Names

Aerinex.

How It Works

Erenumab is a monoclonal antibody, a laboratory-made antibody that functions like the body’s natural immune proteins. It is designed to bind the calcitonin gene-related peptide (CGRP) receptor on target cells.

CGRP contributes to migraine development. By occupying this receptor, the medicine prevents CGRP from attaching, which helps reduce migraine symptoms.

Indications

Erenumab is used to prevent migraine in adults who experience severe, throbbing headaches on one side of the head on at least four days each month. Note that this medicine is not intended to treat an ongoing migraine attack.

Contraindication

Do not use if you have a known hypersensitivity or allergy to any component of erenumab.

The removable needle cap of this product contains latex. Use caution if you are latex-allergic, as the cap may trigger an allergic reaction.

Side Effects

Side effects can occur, though not everyone will experience them. Reported effects include:

• Pain, swelling, or redness at the injection site
• Constipation
• Muscle cramps
• Pruritus

Types

Solution for injection supplied in a prefilled syringe containing 70 mg/mL.

Dosage

For adults with at least 4 migraine days per month, the dose is 70 mg every 4 weeks. If needed, the dose may be increased to 140 mg every 4 weeks. Treatment can be discontinued if there is no improvement after 3 months.

Erenumab is administered by subcutaneous injection. Recommended sites include the abdomen, thigh, or upper arm.

Safety

There are no adequate data for use in pregnant women, breastfeeding individuals, or children under 18 years of age. Use in these groups is not recommended.

Drug Interactions

No clinically significant drug–drug interactions have been reported with erenumab.

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