Other Brands/Names

Actalipid, Atofar, Atorsan, Atorwin, Avesco, Caduet, Debostin, Lipitor, Litorcom, Removcho, Simtor, Starvaz, Stator, Stinator, Torvacard, Truvaz.

How It Works

Atorvastatin works by inhibiting the enzyme responsible for producing cholesterol in the liver, which helps to lower levels of "bad cholesterols" (LDL, Low-Density Lipoproteins). This action helps bring cholesterol levels back into the normal range necessary for the body's proper functioning.

Indications

Atorvastatin is commonly prescribed to treat elevated levels of "bad cholesterols" (LDL) and triglycerides in the blood. Additionally, atorvastatin can help increase levels of "good cholesterols" (HDL). It is used to manage hypercholesterolemia (elevated cholesterol serum levels) and is also employed as a preventive treatment for heart disease in high-risk patients.

Contraindications

Atorvastatin should not be prescribed to individuals who have:

• Acute liver disease

• Unexplained increases in liver enzymes

• Are pregnant or breastfeeding

• Are currently taking the ARV ritonavir to treat HIV/AIDS

• Have a history of hypersensitivity or allergic reactions to atorvastatin

Side Effects

While side effect occurence is rare, some individuals may experience the following side effects:

• Muscle pain

• Elevated liver enzyme levels

• Ringing in the ears (tinnitus)

• Blurred vision

• Diarrhea

• Difficulty defecating

• Nausea

• Vomiting

• Bloating

• Fatigue

• Fever

• Weakness

• Increased blood sugar levels

• Joint pain

Types

Atorvastatin is available in the following forms:

• 10 mg, 20 mg, and 40 mg film-coated tablets

• 10 mg, 20 mg, and 40 mg film-coated caplets

Dosage

For the treatment of hypercholesterolemia

• Adult dosage: 10–80 mg per day

For the prevention of heart disease in high-risk patients

• Adult dosage: Start with 10 mg per day, with the dose adjusted based on LDL cholesterol levels

Safety

Pregnancy:

Atorvastatin is classified as FDA Category X, this means studies of atorvastatin in animals or humans have shown fetal abnormalities, and there is clear evidence of risks to fetus based on adverse reactions. The potential risks of using atorvastatin during pregnancy far outweigh any potential benefits. Therefore, it is not recommended for use in pregnant women.

Drug Interactions

Digoxin

When atorvastatin is used alongside digoxin, it may increase the blood levels of digoxin, raising the risk of digoxin-related side effects. Therefore, medical supervision is required when using these medications together to avoid adverse effects.

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