Other Brands/Names

Prodermal and Trosyid.

How It Works

Tioconazole is an azole antifungal agent used to treat infections caused by fungi or yeast. It works by killing the causative fungus or yeast or preventing its growth.

Indications

Fungal infections of the skin, nails, and vagina (vaginal candidiasis).

Contraindication

Prior history of azole antifungal allergy.

Side Effects

• Contact dermatitis may occur, presenting as burning and irritation at the site where this medicine is applied.
• Headache and burning, itching, or pain in the vagina or urethra (urinary tract) can also appear; if these effects persist or worsen, consult your doctor immediately.
• Very serious allergic reactions are rare, but seek immediate medical attention if you develop a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing.

Types

Tioconazole is available as a cream in 10 g and 20 g tubes. Each gram contains 1% tioconazole.

Dosage

Adults:

• For fungal nail infections: As a 28% solution, apply to the affected nail and surrounding skin every 12 hours for up to 6–12 months. Children: the same as the adult dose.
• For fungal infections of the body: Adults—apply twice daily for 2 to 4 weeks.
• For fungal infections of the feet: Adults—apply twice daily for up to 6 weeks.
• For fungal infections of the groin: Adults—apply twice daily for up to 2 weeks.
• For tinea versicolor (“sun fungus”): Adults—apply twice daily for 1 to 4 weeks.
• For vaginal candidiasis: Adults—use a 6.5% ointment; insert one applicator intravaginally at bedtime as a single dose.

For fungal skin infections in children: the dosage must be determined by a doctor.

Security

• Consult your doctor before using this medicine if you have any of the following: diabetes, immunocompromised (HIV/AIDS), or frequent vaginal yeast infections (more than 3 in 6 months or 4 in 1 year).
• Ask your doctor whether you can have sexual intercourse while using this medicine. Tioconazole may weaken rubber products (such as latex condoms, diaphragms, and cervical caps) and cause failure, which could result in pregnancy. Do not use these products during treatment and for 3 days after completing tioconazole therapy; discuss alternative contraception with your doctor.
• Do not self-medicate during pregnancy. Tioconazole use in pregnancy is only indicated by doctors; discuss risks and benefits with your doctor.
  It is unknown whether this medicine passes into breast milk. Consult your doctor before breastfeeding.

Drug Interactions

Some medicines that may increase the risk of yeast infections include antibiotics, corticosteroids (such as prednisone), and immunosuppressive medicines (such as cyclosporine and methotrexate).

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